5-HT1Dbeta receptor mediates the supersensitivity of isolated coronary artery to serotonin in variant angina

Chest
T IshidaMitsuhiro Yokoyama

Abstract

Although serotonin (5-hydroxytryptamine; 5-HT) is used for provocation of coronary spasm, 5-HT receptor subtypes in spastic coronary arteries remain undetermined. We demonstrated the supersensitivity of isolated coronary artery to ergonovine, 5-HT, and sumatriptan, a 5-HT1D receptor agonist, in a patient with variant angina. Furthermore, we detected gene expression of 5-HT1Dbeta and 5-HT2A receptors in spastic coronary artery using RNase protection assay. These findings suggest that the leftward shift of the dose-response curve for 5-HT, which plays an important role in the pathogenesis of coronary spasm, is mediated by activation of 5-HT1Dbeta receptor.

Citations

Aug 21, 2004·Clinical Neuropharmacology·Sanjeev Wasson, Vinod K S Jayam
May 2, 2003·Expert Opinion on Investigational Drugs·Sheila A Doggrell
Sep 15, 2004·Journal of Toxicology. Clinical Toxicology·Jason B Hack
Jul 23, 2008·Neuropharmacology·Antoinette MaassenVanDenBrinkCarlos M Villalón
Aug 8, 2006·International Journal of Cardiology·Masakatsu ShimizuMitsuhiro Yokoyama
Oct 3, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Feb 13, 2001·Cephalalgia : an International Journal of Headache·K M WelchD Gutterman
May 20, 2004·Headache·Antoinette Maassen Van Den Brink, Pramod R Saxena
Jun 13, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken-Ichi Hirata
Apr 18, 2014·Expert Review of Neurotherapeutics·Rajnish MagoChittaranjan Andrade
Feb 24, 2004·Cardiovascular Drug Reviews·Harjot K SainiNaranjan S Dhalla
Oct 28, 2020·Cardiovascular Intervention and Therapeutics·Satoru SuzukiKenichi Tsujita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.