5-HT1F receptor regulates mitochondrial homeostasis and its loss potentiates acute kidney injury and impairs renal recovery

American Journal of Physiology. Renal Physiology
Whitney S GibbsRick G Schnellmann

Abstract

Our laboratory previously reported that agonists of the 5-hydoxytryptamine 1F (5-HT1F) receptor induce renal mitochondrial biogenesis (MB) and that stimulation of the 5-HT1F receptor following ischemia/reperfusion (I/R)-induced acute kidney injury (AKI) accelerated the recovery of renal function in mice. The goal of this study was to examine the contribution of the 5-HT1F receptor in the regulation of renal mitochondrial homeostasis and renal function in naïve and injured mice. Although 5-HT1F receptor knockout (KO) mice were healthy and fertile, and did not exhibit renal dysfunction, renal mitochondrial DNA copy number and mitochondrial fission gene expression increased at 10 wk of age. The 5-HT1F receptor KO mice exhibited greater proximal tubular injury and diminished renal recovery after I/R-induced AKI compared with wild-type mice. These findings were associated with persistent suppression of renal cortical MB and ATP levels after injury. In summary, the 5-HT1F receptor is a component of physiological MB regulation in the kidney, and its absence potentiates renal injury and impedes recovery.

References

Jan 22, 2003·The European Journal of Neuroscience·Peter G CliftonColin T Dourish
Sep 9, 2006·Pharmacology & Therapeutics·Alberto J Kaumann, Finn Olav Levy
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Mar 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zoltan AranyBruce M Spiegelman
Oct 12, 2010·Biochimica Et Biophysica Acta·Richard C Scarpulla
Mar 1, 2011·Journal of the American Society of Nephrology : JASN·Joel M Weinberg
Dec 14, 2011·American Journal of Physiology. Renal Physiology·Jason A Funk, Rick G Schnellmann
Sep 1, 2012·Science·Richard J Youle, Alexander M van der Bliek
Sep 6, 2012·Heart Failure Reviews·Mariana G Rosca, Charles L Hoppel
Dec 12, 2012·Journal of the American College of Cardiology·Marina BayevaHossein Ardehali
Feb 26, 2013·Antioxidants & Redox Signaling·Zhiyong Cheng, Michael Ristow
May 15, 2013·Nature Reviews. Drug Discovery·Pénélope A AndreuxJohan Auwerx
Sep 18, 2013·The Journal of Pharmacology and Experimental Therapeutics·Ryan M WhitakerRick G Schnellmann
Jan 5, 2014·Current Pathobiology Reports·L Jay StallonsRick G Schnellmann
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Sean R JesinkeyRick G Schnellmann
May 23, 2014·The Journal of Pharmacology and Experimental Therapeutics·Sara M GarrettRick G Schnellmann
Jun 18, 2014·CNS Neuroscience & Therapeutics·Vladimir S NaumenkoEvgeni G Ponimaskin
Apr 22, 2015·Nature·Konstantinos PalikarasNektarios Tavernarakis
Nov 14, 2015·Annual Review of Pharmacology and Toxicology·Ryan M WhitakerRick G Schnellmann
Jan 21, 2016·The Journal of Pharmacology and Experimental Therapeutics·Jennifer L HarmonRick G Schnellmann
Nov 23, 2016·CNS Neuroscience & Therapeutics·Mojtaba GolpichAbolhassan Ahmadiani
Oct 20, 2017·American Journal of Physiology. Renal Physiology·Whitney S GibbsRick G Schnellmann

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Citations

Nov 30, 2019·The Journal of Pharmacology and Experimental Therapeutics·Epiphani C SimmonsRick G Schnellmann
Sep 14, 2019·Cell Death & Disease·Chengyuan TangZheng Dong
Apr 29, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Gagandeep Kaur, Pawan Krishan
Feb 7, 2020·Cells·Ying WangZheng Dong
May 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Sashaina E FanibundaVidita A Vaidya
Mar 3, 2020·Frontiers in Physiology·Mark DomondonDaria V Ilatovskaya
Nov 26, 2020·Nature Reviews. Nephrology·Chengyuan TangZheng Dong
Oct 20, 2020·American Journal of Physiology. Renal Physiology·Mingzhu JiangAihua Zhang
Apr 15, 2020·Experimental Neurology·Epiphani C SimmonsRick G Schnellmann
Jul 27, 2021·Oxidative Medicine and Cellular Longevity·Lini JinFei Han

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BETA
electrophoresis
PCR
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ImageJ
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