PMID: 9423936Jan 10, 1998Paper

5-HT2A/2C receptor agonists potentiate the discriminative cue of (+)-amphetamine in the rat

Neuropharmacology
D Marona-Lewicka, D E Nichols

Abstract

The possible effect of 5-HT2A/2C receptor agonists on an amphetamine-induced behavioral response was examined using the two-lever drug discrimination paradigm. The experiments were designed to investigate an interaction of the hallucinogenic 5-HT2A/2C agonists lysergic acid diethylamide (LSD) and 2,5-dimethoxy-4-iodoamphetamine (DOI), with the discriminative stimulus elicited by a relatively low dose of (+)-amphetamine (1.35 micromol/kg, 0.25 mg/kg, which produced approximately 50% selection of the drug lever). DOI and LSD did not produce amphetamine-like responding at any dose tested or time of administration. However, LSD alone was able to induce a drug-appropriate response in two of nine amphetamine-trained rats. Simultaneous administration of DOI or LSD with amphetamine was not significantly different from the response produced by amphetamine alone. Pre-administration of DOI (3 hr) or of LSD (2 hr) before amphetamine, however, evoked significant enhancement of the amphetamine cue. The results suggest that the enhanced behavioral response to amphetamine may be due either to an increased sensitivity of dopaminergic neurons in the mesolimbic area, or to an enhanced release of dopamine by amphetamine.

References

Dec 31, 1975·Psychopharmacologia·P H Kelly, L L Iversen
May 28, 1975·Psychopharmacologia·M D Schechter, P G Cook
Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·B T Ho, J T Huang
May 8, 1985·European Journal of Pharmacology·E B Nielsen, S A Jepsen
Jan 1, 1986·Medicinal Research Reviews·R Young, R A Glennon
Dec 13, 1974·Nature·L PieriW Haefely
Dec 1, 1984·Pharmacology, Biochemistry, and Behavior·R A GlennonJ D McKenney
Jan 1, 1982·Psychopharmacology·F J White, J B Appel
Jul 30, 1982·European Journal of Pharmacology·A M HoloheanJ B Appel
Apr 1, 1995·Psychopharmacology·V J WattsR B Mailman
May 1, 1995·Pharmacology, Biochemistry, and Behavior·W B WestJ B Appel
Jun 2, 1994·European Journal of Pharmacology·D Marona-Lewicka, D E Nichols
Jul 20, 1993·European Journal of Pharmacology·X Huang, D E Nichols
Jan 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N Iqbal, H M van Praag

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Citations

Dec 4, 1998·Biological Psychiatry·J A LiebermanJ E Kraus
Feb 5, 2016·Pharmacological Reviews·David E Nichols
Jul 10, 2007·European Journal of Pharmacology·Magdalena ZaniewskaMalgorzata Filip
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Sep 6, 2008·Progress in Brain Research·Marcy J Bubar, Kathryn A Cunningham

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