5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide

Epilepsy Research
Borna PayandemehrAhmad Reza Dehpour

Abstract

Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest that 5HT(3) receptors and nitric oxide (NO) might participate in the central effects of SSRIs. In this study in a mouse model of clonic seizure induced by pentylenetetrazole we investigated whether 5-HT(3) receptors are involved in the effects of citalopram on seizure threshold. In our experiments, citalopram at lower doses (0.5 and 1mg/kg, i.p) significantly increased the seizure threshold and at higher doses (≥25mg/kg) showed proconvulsive effects. Moreover, mCPBG (a 5-HT(3) receptor agonist) at low and non-effective doses augmented while non-effective doses of tropisetron prevented the anticonvulsive properties of citalopram. On the other hand, Low doses of nitric oxide synthase inhibitors l-NAME and 7-NI alone or in combination with lower doses of 5-HT(3) receptor agonist enhanced the anticonvulsive property of citalopram, while l-arginine (NO precursor) alone or in combination with tropisetron blocked the protective effect of citalopram. In summary,...Continue Reading

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Citations

Dec 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Borna PayandemehrAhmad Reza Dehpour
Feb 7, 2015·Epilepsy & Behavior : E&B·Borna PayandemehrAhmad Reza Dehpour
Mar 27, 2015·Pharmacotherapy·James McKeanRobert Mokszycki
Jul 29, 2015·Neurochemical Research·Borna PayandemehrAhmad Reza Dehpour
Apr 1, 2015·Pharmacology, Biochemistry, and Behavior·Borna PayandemehrAhmad Reza Dehpour
May 21, 2013·Physiology & Behavior·Borna PayandemehrAhmad Reza Dehpour
Jun 9, 2016·Expert Opinion on Drug Metabolism & Toxicology·Monika BanachStanisław J Czuczwar
Dec 25, 2016·Seizure : the Journal of the British Epilepsy Association·Azhdar Heydari, Shima Davoudi
Jul 11, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yaron FinkelsteinDavid N Juurlink
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Nov 29, 2016·Frontiers in Neuroscience·Dubravka Svob StracGiuseppe Di Giovanni
Dec 26, 2018·Neurological Research·Mehmet Esen, Hatice Aygun
Jun 30, 2018·Current Neuropharmacology·Faheem Hyder PottooMohammad Azam Ansari
Dec 24, 2019·Experimental Neurology·Alexandra N PetrucciGordon F Buchanan
Dec 2, 2017·Epilepsy & Behavior : E&B·Taraneh BahremandAhmad Reza Dehpour

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