5-HTR2A and IL-6 polymorphisms and obstructive sleep apnea-hypopnea syndrome

Biomedical Reports
Wenjuan WuLiang Gu

Abstract

At present, variants of the 5-hydroxytryptamine receptor 2A (5-HTR2A) and interleukin-6 (IL-6) genes may be susceptible markers to develop for obstructive sleep apnea-hypopnea syndrome (OSAHS). Therefore, the aim of the present study was to explore the potential associations between the 5-HTR2A and IL-6 single-nucleotide polymorphisms (SNPs) and OSAHS. In total there were 130 cases and 136 controls collected for genotyping of 5-HTR2A (rs6311) and IL-6 (rs1800796) SNPs. The association of these SNPs with OSAHS risk were evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses with adjustment for gender and age. The results indicated that the genotype and allele frequencies in these two loci (rs6311 and rs1800796) were not significantly different between the cases and controls. However, carrying the 'C' allele of rs6311 has a protective effect against OSAHS via the gender-specific comparison (P=0.0409; OR, 1.744; 95% CI, 1.021-2.978). The 'G' allele and 'CG' genotype distribution of rs1800796, and 'C' allele and 'CT' genotype distribution of rs6311 have significant differences between the mild and moderate group (P<0.05). Similarly, the genotype distr...Continue Reading

References

Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Polina Fenik, Sigrid C Veasey
Dec 31, 2002·American Journal of Human Genetics·Lyle J PalmerSusan Redline
Jan 18, 2003·Sleep Medicine Reviews·Susan Redline, Peter V. Tishler
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Sigrid C Veasey
Jan 21, 2004·Respiration; International Review of Thoracic Diseases·Umur Hatipoğlu, Israel Rubinstein
Feb 2, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Yildirim A BayazitErdogan Inal
Mar 7, 2008·The European Respiratory Journal·N BuriokaE Shimizu
Mar 17, 2009·International Journal of Molecular Medicine·Xiuqin ZhangHong-Tao Zhang
Sep 18, 2010·The European Respiratory Journal·R J KimoffB J Petrof
Jan 7, 2011·Clinical and Translational Science·Emma K LarkinSusan Redline
Jan 28, 2012·Sleep & Breathing = Schlaf & Atmung·Thiago Bittencourt Ottoni de CarvalhoJosé Victor Maniglia
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Oct 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Rashid NadeemRohit Loomba

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Citations

Apr 16, 2020·The Journal of Dermatology·Zhiqiang WangJi Li
Aug 27, 2021·European Journal of Clinical Investigation·Minhan YiYuan Zhang

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