5-HTTLPR and use of antidepressants after colorectal cancer including a meta-analysis of 5-HTTLPR and depression after cancer

Translational Psychiatry
N P SuppliSusanne O Dalton

Abstract

The serotonin-transporter-linked polymorphic region (5-HTTLPR) is one of the most extensively investigated candidates to be involved in gene-environment interaction associated with depression. Nevertheless, the interaction remains controversial. In an original study, we tested the hypothesis that risk for use of antidepressants following a diagnosis of colorectal cancer is associated with bi- and triallelic genotypes of 5-HTTLPR. In addition, in an inclusive meta-analysis, we tested the hypothesis that depression following a diagnosis of cancer is associated with biallelic 5-HTTLPR genotype. We created an exposed-only cohort of 849 colorectal cancer patients from the Danish Diet, Cancer and Health cohort study. The hypothesized association was investigated with Cox regression models and competing risk analyses. Five studies comprising a total of 1484 cancer patients were included in the meta-analysis. Nationwide registries provided information on dates of diagnosis of colorectal cancer and use of antidepressants. Unadjusted odds ratios of depression according to the biallelic 5-HTTLPR genotype were included in the meta-analysis. 5-HTTLPR genotypes were not associated with use of antidepressants after colorectal cancer. Estimate...Continue Reading

References

Jun 1, 1996·Journal of Neurochemistry·A HeilsK P Lesch
Feb 1, 2002·Psychiatric Services : a Journal of the American Psychiatric Association·Danielle L LoosbrockThomas W Croghan
Mar 3, 2004·Computer Methods and Programs in Biomedicine·Susanne RosthøjSteen Z Abildstrom
Aug 12, 2008·Biological Psychiatry·Marcus R MunafòJonathan Flint
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susanne O DaltonChristoffer Johansen
Jun 18, 2009·JAMA : the Journal of the American Medical Association·Neil RischKathleen Ries Merikangas
Feb 4, 2010·Journal of Affective Disorders·Luigi GrassiTullio Giraldi
Aug 4, 2011·Scandinavian Journal of Public Health·Helle Wallach KildemoesJesper Hallas
Aug 4, 2011·Scandinavian Journal of Public Health·Ole MorsPreben Bo Mortensen
Aug 4, 2011·Scandinavian Journal of Public Health·Flemming PeterssonLau Caspar Thygesen
Dec 3, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kyung Ran KimKee Namkoong
Jun 19, 2012·European Journal of Clinical Pharmacology·Gianluca TrifiròFabio Samani
Nov 6, 2012·Psycho-oncology·Jeff DunnSuzanne K Chambers
Feb 16, 2013·Radiology and Oncology·Giulia SchillaniTullio Giraldi
Nov 14, 2013·BMC Psychiatry·Robert C CulverhouseUNKNOWN 5-HTTLPR, Stress, and Depression Consortium
Mar 1, 2006·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Terrie E MoffittMichael Rutter

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Citations

Jul 15, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Klaske van NorrenRenger F Witkamp

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KBioscience Kraken
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