5-HTTLPR polymorphism: analysis in South African autistic individuals

Human Biology
Zainunisha ArieffVladimir B Bajic

Abstract

The serotonin transporter promoter length polymorphism (5-hydroxytryptamine transporter length polymorphism; 5-HTTLPR) has long been implicated in autism and other psychiatric disorders. The use of selective serotonin reuptake inhibitors (SSRIs) has a positive effect on treating some symptoms of autism. The effects of these drugs vary in individuals because of the presence of the S or L allele of 5-HTTLPR. Studies performed on various autistic populations have found different allele frequencies for the L and S alleles. Allele frequencies and genotypes of the South African autistic populations (African, mixed, and Caucasian) were compared with matching South African ethnic control populations. The *S/*S genotype was found to be highly significantly associated with all the South African autistic ethnic populations. In the South African African population the *S/*S genotype was present in 7 (33%) of the autistic individuals but in none of the control subjects, yielding infinitely large odds of developing autism. The odds of developing autism with the *S/*S genotype compared to the *L/*L genotype increased 10.15-fold in the South African mixed group and 2.74-fold in the South African Caucasian population. The allele frequency of th...Continue Reading

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Citations

Sep 28, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Preeti JaiswalUsha Rajamma
Mar 16, 2013·Autism Research : Official Journal of the International Society for Autism Research·Rebecca A HarringtonIrva Hertz-Picciotto
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May 30, 2015·Neuroscience and Biobehavioral Reviews·Preeti JaiswalUsha Rajamma
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Oct 11, 2021·BMC Neuroscience·Diego Alejandro Rodriguez-GomezClaudia Talero-Gutiérrez

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Methods Mentioned

BETA
Genotyping
PCR
Electrophoresis

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Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

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