5-HTTLPR polymorphism impacts task-evoked and resting-state activities of the amygdala in Han Chinese.

PloS One
Sufang LiYu-Feng Zang

Abstract

Prior research has shown that the amygdala of carriers of the short allele (s) of the serotonin transporter (5-HTT) gene (5-HTTLPR) have a larger response to negative emotional stimuli and higher spontaneous activity during the resting state than non-carriers. However, recent studies have suggested that the effects of 5-HTTLPR may be specific to different ethnic groups. Few studies have been conducted to address this issue. Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was conducted on thirty-eight healthy Han Chinese subjects (l/l group, n = 19; s/s group, n = 19) during the resting state and during an emotional processing task. Compared with the s/s group, the l/l group showed significantly increased regional homogeneity or local synchronization in the right amygdala during the resting state (|t|>2.028, p<0.05, corrected), but no significant difference was found in the bilateral amygdala in response to negative stimuli in the emotional processing task. 5-HTTLPR can alter the spontaneous activity of the amygdala in Han Chinese. However, the effect of 5-HTTLPR on the amygdala both in task state and resting state in Asian population was no similar with Caucasians. They suggest that the eff...Continue Reading

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Citations

Aug 21, 2015·Brain, Behavior, and Immunity·Valerio Napolioni, James MacMurray
Nov 29, 2015·Brain Imaging and Behavior·Hongchang ZhaiFucang Jia
Jun 23, 2015·Human Brain Mapping·Aldo Córdova-PalomeraLourdes Fañanás
Sep 12, 2019·Social Cognitive and Affective Neuroscience·Yafang YangPingyuan Gong
Jul 10, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Marieke KleinBarbara Franke

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Methods Mentioned

BETA
imaging techniques
genotyping
PCR

Software Mentioned

AFNI
SPM8
REST
Resting
- State fMRI Data Analysis Toolkit ( REST
SPSS
AlphaSim
ReHo

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