5-hydroxydecanoate selectively reduces the initial increase in extracellular K+ in ischemic guinea-pig heart

European Journal of Pharmacology
K SakamotoT Nagao

Abstract

The aim of the present study was to determine the effect of 5-hydroxydecanoate (5-HD) on extracellular K+ levels during global ischemia for 30 min employing K+-sensitive electrodes in isolated guinea-pig hearts. 5-HD (100 microM) reduced the K+ accumulation during the early period of ischemia, but did not inhibit the elevation of extracellular K+ in the latter half of the ischemic period which was selectively enhanced by ouabain (3 microM). Thus, 5-HD appears to exert a similar mode of action as glibenclamide on extracellular K+ accumulation in the ischemic guinea-pig hearts. The present study also strengthens the previous conclusion that an ATP-sensitive K+ channel contributes only to the initial increasing phase of extracellular K+ accumulation during ischemia in guinea-pig hearts.

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Citations

May 4, 2001·European Journal of Pharmacology·K SakamotoK Ishii
Jan 10, 2002·European Journal of Pharmacology·Ryuichi SatoTaku Nagao
Jul 29, 2010·Physiological Reviews·Thomas P FlaggColin G Nichols
Jun 25, 2013·Pharmacology & Therapeutics·William A Coetzee
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Ming-Lei ZhuoChih-Chuan Liang
Nov 14, 2000·Circulation Research·B O'Rourke
Sep 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jonna R TerkildsenNicolas P Smith
Dec 15, 2015·Physiological Reviews·Monique N Foster, William A Coetzee
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·G Y WangT M Wong
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·B RodríguezB Trénor

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