5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.

Biological Psychiatry
John P ChristiansonSteven F Maier

Abstract

Exposure to uncontrollable stressors often increases anxiety-like behavior in both humans and rodents. In rat, this effect depends on stress-induced activity within the dorsal raphe nucleus (DRN). However, the role of serotonin in DRN projection regions is largely unknown. The goals of this study were to 1) assess the effect of uncontrollable stress on extracellular serotonin in the basolateral amygdala during the anxiety test, 2) determine whether DRN activity during a poststress anxiety test is involved in anxiety-like behavior, and 3) determine the role of the serotonin 2C receptor (5-HT(2C)) in uncontrollable stress-induced anxiety. Rats were exposed to tail shocks that were either controllable or uncontrollable. On the following day, anxiety-like behavior was assessed in a Juvenile Social Exploration (JSE) test. Basolateral amygdala (BLA) extracellular serotonin concentrations were assessed during JSE by in vivo microdialysis 24 hours after uncontrollable stress, controllable stress, or no stress. In separate experiments, drugs were administered before the JSE test to inhibit the DRN or to block 5-HT(2C) receptors. Exposure to uncontrollable shock reduced later social exploration. Prior uncontrollable stress potentiated se...Continue Reading

References

Apr 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·S F Maier
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Jan 1, 1993·Psychopharmacology·S L Handley, J W McBlane
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·K R Short, S F Maier
Jan 1, 1996·Neuropharmacology·J P Huidobro-ToroR A Harris
Apr 1, 1997·Reviews in the Neurosciences·L E RueterB L Jacobs
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L G KirbyR J Valentino
Feb 5, 2002·Expert Opinion on Pharmacotherapy·L L DavisF Petty
Feb 26, 2003·European Journal of Pharmacology·Sandra E File, Pallab Seth
Feb 26, 2003·European Journal of Pharmacology·David L WalkerMichael Davis
May 3, 2003·Biological Psychiatry·Richard A Bryant
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Jan 21, 2006·Stress : the International Journal on the Biology of Stress·Anantha ShekharTammy Sajdyk
Jan 21, 2006·Stress : the International Journal on the Biology of Stress·Christopher A LowryAnantha Shekhar
Sep 19, 2006·Biological Psychiatry·Rupert R LanzenbergerJohannes Tauscher
Apr 25, 2007·Genes, Brain, and Behavior·L K HeislerL H Tecott
Aug 25, 2007·Annual Review of Clinical Psychology·Steven M SouthwickDennis S Charney
Jun 4, 2008·Archives of General Psychiatry·Richard A BryantMark Creamer
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John P ChristiansonSteven F Maier

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Citations

Mar 16, 2013·Histochemistry and Cell Biology·Esther AsanKlaus-Peter Lesch
Apr 17, 2013·Pflügers Archiv : European journal of physiology·Nina C Donner, Christopher A Lowry
Apr 10, 2012·Cellular and Molecular Neurobiology·Matthew W HaleChristopher A Lowry
Mar 19, 2013·Behavioural Brain Research·Christiana Villela de Andrade StraussHelio Zangrossi
Oct 25, 2011·Development and Psychopathology·Theodore P BeauchaineNatalia Potapova
Feb 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Igor PonomarevMichael S Fanselow
Apr 22, 2011·Exercise and Sport Sciences Reviews·Benjamin N Greenwood, Monika Fleshner
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick M Fisher, Ahmad R Hariri
Jan 1, 2011·Biology of Mood & Anxiety Disorders·Patrick M FisherAhmad R Hariri
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brian J MickeyJon-Kar Zubieta
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juan A VarelaDonald C Cooper
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert R RozeskeSteven F Maier
Mar 25, 2014·Neuroscience and Biobehavioral Reviews·Hélio Zangrossi, Frederico G Graeff
Aug 25, 2012·Expert Opinion on Investigational Drugs·Gaël QuesseveurBruno P Guiard
Aug 14, 2013·Molecular Pain·Stéphanie Grégoire, Volker Neugebauer
Mar 5, 2013·Physiology & Behavior·Robert S ThompsonMonika Fleshner
May 31, 2011·Journal of Chemical Neuroanatomy·Ross A McDevitt, John F Neumaier
Apr 19, 2011·Trends in Pharmacological Sciences·Judit LazaryGyorgy Bagdy
Dec 1, 2015·Pharmacology & Therapeutics·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Jul 22, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matthew W HaleChristopher A Lowry
Sep 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Allison R Foilb, John P Christianson
Nov 6, 2013·The European Journal of Neuroscience·Jeyce W Quintino-dos-SantosLuiz C Schenberg
May 28, 2014·The European Journal of Neuroscience·Jose AmatSteven F Maier
Apr 20, 2016·Frontiers in Neuroanatomy·Fabio N SantosFrancisco E Olucha-Bordonau

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