5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved.

BMC Pharmacology
Robert Patrick DavisStephanie W Watts

Abstract

Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 ...Continue Reading

References

Sep 4, 1992·European Journal of Pharmacology·M BodelssonB Arneklo-Nobin
Jan 1, 1990·Cardiovascular Drugs and Therapy·N FetkovskaF R Buhler
May 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M T LinB L Tsay
May 1, 1994·Clinical and Experimental Pharmacology & Physiology·O L Woodman, G J Dusting
May 19, 1998·Life Sciences·O YildizR E Purdy
May 27, 1999·Naunyn-Schmiedeberg's Archives of Pharmacology·P De VriesP R Saxena
Jan 28, 2003·Journal of Cardiovascular Pharmacology·Husamettin GulDervis Sen
Sep 17, 2003·BMC Pharmacology·Amy K L Banes, Stephanie W Watts
Jan 31, 2004·Pharmacology, Biochemistry, and Behavior·Srividya Subramanian, Regis R Vollmer
Feb 24, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·S JähnichenH H Pertz
Apr 14, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·David N Proctor, Beth A Parker
May 18, 2007·Journal of Neurochemistry·B BrennerF Kilic
Feb 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jessica DiazStephanie W Watts
May 1, 2008·The European Journal of Neuroscience·Yasushi NakataniHideho Arita
May 4, 2010·Cardiovascular Therapeutics·Stephanie W Watts, Robert Patrick Davis

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Citations

Feb 19, 2015·Pharmacology Research & Perspectives·Stephanie W WattsJanice M Thompson
Mar 30, 2016·Pharmacology Research & Perspectives·Emilie M OutzenMajid Sheykhzade
Aug 1, 2015·Histochemistry and Cell Biology·Lindsey W YoungStephanie W Watts
Nov 28, 2012·Cell Calcium·N R TykockiS W Watts
May 28, 2019·Physiological Genomics·Bridget M SeitzStephanie W Watts
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W Watts
Jun 20, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Bridget M SeitzStephanie W Watts
May 25, 2021·Journal of Cardiovascular Pharmacology·Romina Gonzalez-PonsStephanie W Watts

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Methods Mentioned

BETA
PCR
SMA
dissection

Software Mentioned

GraphPad Prism

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