5-Hydroxytryptamine and arachidonic acid metabolites modulate extensive platelet activation induced by collagen in cats in vivo

British Journal of Pharmacology
F De ClerckP A Janssen

Abstract

1. The pathways contributing to the platelet adhesion/aggregation reaction elicited by collagen microfibrils, administered to cats in vivo, were analysed. 2. The intra-aortic infusion of collagen (100 micrograms kg-1 in 1 min) caused an extensive activation of platelets, as evidenced by the time-dependent drop of free platelet numbers in whole blood, and the increases of 5-hydroxyindoles (5-HI), 5-hydroxytryptamine (5-HT) and thromboxane B2 (TXB2) levels in plasma, prepared from effluent venous blood sampled from the inferior caval vein. 3. 5-HT2 receptor blockade with ketanserin (0.63 mg kg-1 i.v., 10 min) and cyclo-oxygenase inhibition with aspirin (10 mg kg-1 i.v., 10 min) slightly attenuated the peak reduction of free platelets in whole blood in response to collagen without affecting changes in plasma 5-HI. Aspirin, but not ketanserin, reduced the collagen-induced changes in plasma TXB2, prostaglandin E2 (PGE2) and 6K-PGF1 alpha. 4. Dual TXA2 synthetase inhibition/TXA2-prostaglandin endoperoxide receptor antagonism with ridogrel (5 mg kg-1 i.v., 10 min) halved the drop in free platelets, reduced the release of platelet 5-HI, inhibited the increase in plasma TXB2 and elevated that of 6K-PGF1 alpha and PGE2 in response to col...Continue Reading

References

Oct 1, 1979·European Journal of Pharmacology·B B VargaftigF Fouque
Oct 16, 1986·The New England Journal of Medicine·D J FitzgeraldG A FitzGerald
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Dec 1, 1984·Agents and Actions·F De ClerckR S Reneman
Jan 1, 1983·Archives of Internal Medicine·C H PuiC Chesney
Feb 1, 1984·Thrombosis Research·F De ClerckP A Janssen
Nov 1, 1980·The Journal of Clinical Investigation·A J MarcusM J Broekman
Feb 15, 1981·Biochemical Pharmacology·B B VargaftigJ Benveniste

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Citations

Oct 31, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BarradasD P Mikhailidis
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Marie-Claude BlaisClaire R Sharp
Feb 14, 2019·Blood·Mohamad Fadhli Bin MasriAshley L St John
Nov 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S KaulJ A Lopez

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