5-Hydroxytryptamine does not reduce sympathetic nerve activity or neuroeffector function in the splanchnic circulation

European Journal of Pharmacology
Emma S DariosStephanie W Watts

Abstract

Infusion of 5-hydroxytryptamine (5-HT) in conscious rats results in a sustained (up to 30 days) fall in blood pressure. This is accompanied by an increase in splanchnic blood flow. Because the splanchnic circulation is regulated by the sympathetic nervous system, we hypothesized that 5-HT would: 1) directly reduce sympathetic nerve activity in the splanchnic region; and/or 2) inhibit sympathetic neuroeffector function in splanchnic blood vessels. Moreover, removal of the sympathetic innervation of the splanchnic circulation (celiac ganglionectomy) would reduce 5-HT-induced hypotension. In anaesthetized Sprague-Dawley rats, mean blood pressure was reduced from 101±4 to 63±3mm Hg during slow infusion of 5-HT (25μg/kg/min, i.v.). Pre- and postganglionic splanchnic sympathetic nerve activity were unaffected during 5-HT infusion. In superior mesenteric arterial rings prepared for electrical field stimulation, neither 5-HT (3, 10, 30nM), the 5-HT1B receptor agonist CP 93129 nor 5-HT1/7 receptor agonist 5-carboxamidotryptamine inhibited neurogenic contraction compared to vehicle. 5-HT did not inhibit neurogenic contraction in superior mesenteric venous rings. Finally, celiac ganglionectomy did not modify the magnitude of fall or time ...Continue Reading

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Citations

Aug 5, 2017·Clinical and Experimental Pharmacology & Physiology·José-Ángel García-PedrazaAsunción Morán
Nov 3, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Stephanie W Watts
Jun 20, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Bridget M SeitzStephanie W Watts
Jan 31, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·José Ángel García-PedrazaAsunción Morán
Apr 15, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rafael CamposGilberto De Nucci

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