5-Hydroxytryptamine-induced bronchoconstriction in the guinea-pig: effect of 5-HT2 receptor activation on acetylcholine release

British Journal of Pharmacology
I Macquin-MavierA Harf


1. The bronchoconstrictor responses to 5-hydroxytryptamine (5-HT) were studied in the guinea-pig to establish whether they are partly attributable to parasympathetic activation within the airways. 5-HT dose-response curves were constructed in anaesthetized and ventilated guinea-pigs pretreated with saline, or by bilateral cervical vagotomy or vagotomy plus atropine 3 mg kg-1, i.v. Vagotomy had no effect on 5-HT-induced bronchoconstriction but vagotomy plus atropine significantly reduced it. 2. To determine whether parasympathetic activation within the airways resulted from pre- or postganglionic stimulation, 5-HT dose-response curves were constructed for two groups of vagotomized guinea-pigs treated with hexamethonium 2 mg kg-1, or hexamethonium 2 mg kg-1, plus atropine 3 mg kg-1. Guinea-pigs treated with hexamethonium plus atropine experienced significantly less 5-HT-induced bronchoconstriction than those treated with hexamethonium alone. 3. To characterize the subtype of 5-HT receptors involved in the activation of the parasympathetic system by 5-HT, dose-response curves to 5-HT were constructed for four groups of vagotomized guinea-pigs treated with saline, 1 mg kg-1 of the 5-HT3 antagonist ICS 205-930, or either 0.01 or 0.1...Continue Reading


Dec 17, 1991·European Journal of Pharmacology·A J Van OosterhoutF P Nijkamp
Feb 16, 1993·European Journal of Pharmacology·J L SzarekC A Gruetter
Mar 30, 1993·European Journal of Pharmacology·C A RizzoR W Chapman
Dec 4, 2003·Pulmonary Pharmacology & Therapeutics·A M DodsonK J Rhoden
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F LechinA E Lechin
Jan 1, 1995·Allergy·M CazzolaF Rossi
Sep 29, 2011·British Journal of Pharmacology·R MakwanaC Page
Aug 12, 2014·Regulatory Toxicology and Pharmacology : RTP·Xiaofang ZhangGuocai Lu
Jun 1, 1993·Cephalalgia : an International Journal of Headache·D K Lloyd, A J Pilgrim
Aug 13, 1999·The American Journal of Physiology·M A OlszewskiN E Robinson


Feb 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H L HahnJ A Nadel
Oct 1, 1975·British Journal of Pharmacology·D I Wallis, B Woodward
Nov 1, 1989·Journal of Applied Physiology·C ClericiA Harf
Mar 1, 1989·Journal of Applied Physiology·I Macquin-MavierA Harf
Feb 1, 1987·Journal of Applied Physiology·A R LeffN P Stimler-Gerard
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·H Lemoine, A J Kaumann
Feb 1, 1985·Journal of Applied Physiology·S A ShoreJ G Martin
Oct 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M M GrunsteinJ S Grunstein
Jul 1, 1984·British Journal of Pharmacology·C AdvenierA Renier

Related Concepts

Parasympathetic Nerve Structure
Alpha-Methyltyrosine Hydrochloride
Bronchoconstrictor Agents
Receptors, Tryptamine
Serotonin 5-HT2 Receptor Agonists

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.