5-Hydroxytryptamine-induced bronchoconstriction in the guinea-pig: effect of 5-HT2 receptor activation on acetylcholine release

British Journal of Pharmacology
I Macquin-MavierA Harf

Abstract

1. The bronchoconstrictor responses to 5-hydroxytryptamine (5-HT) were studied in the guinea-pig to establish whether they are partly attributable to parasympathetic activation within the airways. 5-HT dose-response curves were constructed in anaesthetized and ventilated guinea-pigs pretreated with saline, or by bilateral cervical vagotomy or vagotomy plus atropine 3 mg kg-1, i.v. Vagotomy had no effect on 5-HT-induced bronchoconstriction but vagotomy plus atropine significantly reduced it. 2. To determine whether parasympathetic activation within the airways resulted from pre- or postganglionic stimulation, 5-HT dose-response curves were constructed for two groups of vagotomized guinea-pigs treated with hexamethonium 2 mg kg-1, or hexamethonium 2 mg kg-1, plus atropine 3 mg kg-1. Guinea-pigs treated with hexamethonium plus atropine experienced significantly less 5-HT-induced bronchoconstriction than those treated with hexamethonium alone. 3. To characterize the subtype of 5-HT receptors involved in the activation of the parasympathetic system by 5-HT, dose-response curves to 5-HT were constructed for four groups of vagotomized guinea-pigs treated with saline, 1 mg kg-1 of the 5-HT3 antagonist ICS 205-930, or either 0.01 or 0.1...Continue Reading

References

Dec 17, 1991·European Journal of Pharmacology·A J Van OosterhoutF P Nijkamp
Feb 16, 1993·European Journal of Pharmacology·J L SzarekC A Gruetter
Mar 30, 1993·European Journal of Pharmacology·C A RizzoR W Chapman
Dec 4, 2003·Pulmonary Pharmacology & Therapeutics·A M DodsonK J Rhoden
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F LechinA E Lechin
Jan 1, 1995·Allergy·M CazzolaF Rossi
Sep 29, 2011·British Journal of Pharmacology·R MakwanaC Page
Aug 12, 2014·Regulatory Toxicology and Pharmacology : RTP·Xiaofang ZhangGuocai Lu
Jun 1, 1993·Cephalalgia : an International Journal of Headache·D K Lloyd, A J Pilgrim
Aug 13, 1999·The American Journal of Physiology·M A OlszewskiN E Robinson

Citations

Feb 1, 1978·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·H L HahnJ A Nadel
Oct 1, 1975·British Journal of Pharmacology·D I Wallis, B Woodward
Nov 1, 1989·Journal of Applied Physiology·C ClericiA Harf
Mar 1, 1989·Journal of Applied Physiology·I Macquin-MavierA Harf
Feb 1, 1987·Journal of Applied Physiology·A R LeffN P Stimler-Gerard
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·H Lemoine, A J Kaumann
Feb 1, 1985·Journal of Applied Physiology·S A ShoreJ G Martin
Oct 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M M GrunsteinJ S Grunstein
Jul 1, 1984·British Journal of Pharmacology·C AdvenierA Renier

Related Concepts

Demser
Parasympathetic Nerve Structure
Alpha-Methyltyrosine Hydrochloride
Cavia
Serotonin
Bronchoconstrictor Agents
Receptors, Tryptamine
Atropine
Serotonin 5-HT2 Receptor Agonists
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