5-Hydroxytryptamine initiates pulsatile urea excretion from perfused gills of the gulf toadfish (Opsanus beta)

Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
M Danielle McDonaldChris M Wood

Abstract

When stressed, toadfish become ureotelic and excrete almost all of their nitrogenous waste in 1-3 daily pulses of urea-N across the gills. Intravascular injections of 5-hydroxytyptamine (5-HT; serotonin) and analogues also elicit marked excretory pulses of urea-N from toadfish in vivo, suggesting that 5-HT release is the proximate trigger for spontaneous pulses. However it is unclear whether 5-HT is acting on the gills directly or elsewhere to cause the effect indirectly. A perfused whole gill preparation which maintained normal pressure relationships and stable vascular resistance was employed to address this question. Bolus injections into the ventral aortic perfusate of either 5-HT (1, 10 μmol kg(-1)) or the specific 5-HT(2) receptor agonist α-methyl 5-HT (1, 10 μmol kg(-1)) elicited rapid urea-N pulses from perfused toadfish gills. The effective doses, the post-injection delays (5.5 ± 1.3 min, range=2-22), the percent occurrences (57-85%), and the magnitude of the induced urea-N pulses (615.4 ± 131.3 μmol-N kg(-1), range 66.0-2634.0), were all similar to those previously reported when these agents were injected in vivo. Bolus injections of 5-HT and α-methyl 5-HT also elicited a biphasic response in ventral aortic pressure, ...Continue Reading

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Citations

Jun 12, 2012·Respiratory Physiology & Neurobiology·M Danielle McDonaldPatrick J Walsh
Jul 19, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Maria C CartolanoM Danielle McDonald

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