5-Hydroxytryptophan-induced myoclonus in guinea pigs: mediation through 5-HT1/2 receptor subtypes

European Journal of Pharmacology
E J PappertP M Carvey

Abstract

In guinea pigs, myoclonus can be induced by 5-hydroxytryptamine (5-HT, serotonin) precursors and synthetic 5-HT receptor agonists, yet the receptor subtype specificity of this behavior is not fully delineated. Guinea pigs were pre-treated with carbidopa (50 mg) followed by one of eight 5-HT antagonists: (-)-N-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenyl propionamide ((-)-WAY 100135) (5-HT1A), N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-N-(2-pyridyl)-cy clohexancarboxamide (WAY 100635) (5-HT1A), methiothepin mesylate (5-HT1/2), mesulergine hydrochloride (5-HT2A/2C), N[4-methoxy-3-(4-methyl-L-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1,2 ,4-oxadizol-3-yl) (GR 127935) (5-HT1D), trans-4-[(3Z)3-(2-dimethylaminoethyl)oxyimino-3(2-fluorop hen yl) propen-1-yl]phenol, hemifumarate (SR 46349) (5-HT2), ondansetron hydrochloride (5-HT3), and [1-[2-[methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-meth oxy-1H-indole-3-carboxylate (GR 125487) (5-HT4). Thirty minutes later, they received 5-hydroxytryptophan (5-HTP) (75 mg/kg, sc) and myoclonic jumping rates were assessed every 10 min for 200 min by a blinded observer. Repeated measures analysis of variance of drug-induced antagonism of 5-HTP-induced myoclonus re...Continue Reading

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Citations

Oct 24, 2012·Reviews in the Neurosciences·Robert LalondeCatherine Strazielle
Jan 20, 2004·CNS Drugs·Félix Javier Jiménez-JiménezMaría de Toledo-Heras
Jun 23, 2000·Journal of the American Veterinary Medical Association·S M Gwaltney-BrantS A Khan
Nov 16, 2013·Experimental Brain Research·Mohammad Hadi GharedaghiReza Rahimian
Oct 24, 2006·Neuroscience and Biobehavioral Reviews·L Giménez-LlortA Fernández-Teruel
May 20, 2003·Pharmacology & Toxicology·Laura Osorio-RicoCamilo Ríos
Oct 23, 2013·Behavioural Brain Research·R Baeta-Corral, L Giménez-Llort
Aug 12, 2016·Journal of Anesthesia·Sook Hui ChawLi Lian Foo
Jul 25, 2012·Neuroscience Research·R Lalonde, C Strazielle
Dec 25, 2004·Behavioural Brain Research·R LalondeC Strazielle
Jun 26, 2015·Journal of Virology·Bernardo A MainouTerence S Dermody
Oct 18, 2019·Yeungnam University Journal of Medicine·Kwan-Do ParkSe-Jin Lee
Sep 19, 2003·Journal of Child Neurology·Terence D Sanger
Apr 24, 2020·Yeungnam University Journal of Medicine·Seong Yoon Bae, Se-Jin Lee

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