5-Hz stimulation of CA3 pyramidal cell axons induces a beta-adrenergic modulated potentiation at synapses on CA1, but not CA3, pyramidal cells

Brain Research
T D MoodyThomas J O'Dell

Abstract

In mouse hippocampal slices, long-term potentiation (LTP) at Schaffer collateral fiber synapses onto CA1 pyramidal cells could be induced by brief trains of 5-Hz synaptic stimulation (30 s) or by longer trains of 5-Hz stimulation (3 min) delivered during beta-adrenergic receptor activation. In contrast, 5-Hz stimulation, either alone or in the presence of the beta-adrenergic receptor agonist isoproterenol, failed to induce LTP at associational-commissural (assoc-com) fiber synapses onto CA3 pyramidal cells. Our results suggest that although CA3 pyramidal cells give rise to both the Schaffer collateral fiber synapses in CA1 and the assoc-com fiber synapses in CA3, the induction of LTP at these synapses may be regulated by different activity- and modulatory neurotransmitter-dependent processes.

References

Feb 15, 1980·The Journal of Comparative Neurology·R LoyR Y Moore
Oct 20, 1994·Nature·L CahillJ L McGaugh
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

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Citations

Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yan-You Huang, Eric R Kandel
May 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Kristin L HillmanJames E Porter
Mar 20, 2015·Journal of Neuroscience Research·Tomasz Wójtowicz, Jerzy W Mozrzymas

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