5-Lipoxygenase and 5-lipoxygenase activating protein (FLAP) immunoreactivity in lungs from patients with primary pulmonary hypertension

American Journal of Respiratory and Critical Care Medicine
L WrightNorbert F Voelkel

Abstract

Inflammatory infiltrates and endothelial cell proliferation have been appreciated in plexiform and concentric lesions, which characterize the vascular remodeling in primary pulmonary hypertension (PPH). Leukotriene production by perivascular and alveolar macrophages relies on activation of 5-lipoxygenase (5-LO), with translocation of the enzyme to the nuclear membrane, and association with the 5-LO activating protein (FLAP). Using immunohistochemical staining, we localized and semi-quantitatively estimated the abundance of 5-LO and FLAP in lungs obtained from patients with PPH, patients with interstitial lung disease (ILD), and normal control subjects. Expression of 5-LO and FLAP was prominent in alveolar macrophages in both the normal and PPH lungs; however, alveolar macrophages were more frequently clustered in the vicinity of remodeled blood vessel in PPH. Medium- and small-size pulmonary arteries in PPH showed more abundant FLAP expression than in control and ILD lungs. 5-LO expression in small arteries in PPH was more intense than in control and ILD patients. Endothelial cells in plexiform and concentric lesions in PPH expressed both 5-LO and FLAP. In situ hybridization confirmed the presence of 5-LO transcripts in macroph...Continue Reading

References

Sep 1, 1992·Journal of Applied Physiology·S OnoN F Voelkel
Dec 1, 1992·The Journal of Cell Biology·S KargmanJ F Evans
May 1, 1992·The Journal of Clinical Investigation·M D BotneyR P Mecham
Jan 1, 1990·Histopathology·A W CaslinP Smith
Jan 1, 1987·Respiration; International Review of Thoracic Diseases·G G Pietra, J R Rüttner
Aug 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E J GoetzlW L Smith
Jan 1, 1994·Annual Review of Biochemistry·A W Ford-HutchinsonR N Young
Jun 17, 1993·The New England Journal of Medicine·A GiaidD J Stewart
Apr 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K M AndersonJ E Harris
Feb 1, 1996·The Journal of Clinical Investigation·I M AvisJ L Mulshine
Apr 15, 1996·The Journal of Clinical Investigation·J WilbornM Peters-Golden
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D G TangK V Honn

❮ Previous
Next ❯

Citations

Feb 15, 2012·The Journal of Physiological Sciences : JPS·Daling Zhu, Yajuan Ran
Jul 13, 2004·Autoimmunity Reviews·Patricia E Carreira
Jan 5, 2002·The Biochemical Journal·Ying-Yi ZhangJoseph Loscalzo
Jan 9, 2008·The Journal of Experimental Medicine·Hong QiuJesper Z Haeggström
Dec 10, 2002·Antioxidants & Redox Signaling·Rubin M Tuder, Norbert F Voelkel
Apr 30, 2003·Antioxidants & Redox Signaling·Valerie B O'Donnell
Nov 22, 2007·Journal of Cardiovascular Pharmacology·Colin D Funk, Garret A FitzGerald
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Tamera J CorteS John Wort
Aug 30, 2013·Science Translational Medicine·Wen TianMark R Nicolls
Jun 17, 2011·Respiration; International Review of Thoracic Diseases·Georgia PitsiouDemosthenes Bouros
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·R M TuderN F Voelkel
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·M Peters-Golden, T G Brock
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·H KimuraT Kuriyama
Jan 1, 2004·American Journal of Respiratory and Critical Care Medicine·Rebecca BowersNorbert F Voelkel
Jun 25, 2004·American Journal of Respiratory and Critical Care Medicine·Todd M BullMark W Geraci
Jan 27, 2007·American Journal of Respiratory and Critical Care Medicine·Steven D NathanRubin M Tuder
Oct 13, 2007·American Journal of Respiratory and Critical Care Medicine·Barbara O MeyrickJames E Loyd
Jul 5, 2013·American Journal of Respiratory and Critical Care Medicine·Jacob P Scott, Marc Peters-Golden
Oct 2, 2004·The New England Journal of Medicine·Marc HumbertGérald Simonneau
Jul 24, 1998·Chest·R M TuderC C Cool
Dec 27, 2015·The American Journal of Medicine·Inderjit SinghDavid Adam Berlin
Dec 24, 2005·Chest·Carlyne D CoolNorbert F Voelkel
Feb 1, 2011·Journal of Pharmacological and Toxicological Methods·Robert F Wideman, Krishna R Hamal
Jul 8, 2009·European Journal of Pharmacology·Luz A Cortes-BurgosJaime L Masferrer
Oct 24, 2007·Journal of Molecular and Cellular Cardiology·Stephen Y Chan, Joseph Loscalzo
Dec 23, 2006·Seminars in Thoracic and Cardiovascular Surgery·Richard S SacksJason X-J Yuan
Feb 27, 2014·Immunologic Research·Wen TianMark R Nicolls
Mar 31, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Robert F WidemanNicholas B Anthony
Apr 27, 2010·European Journal of Clinical Investigation·R De CaterinaJ Maclouf
May 28, 2004·Pharmacology & Therapeutics·Horst OlschewskiWerner Seeger
Oct 10, 2001·Clinics in Chest Medicine·P HerveG Simonneau
Aug 11, 2004·Cardiology Clinics·Norbert F Voelkel, Carlyne Cool
Apr 4, 2015·The Canadian Journal of Cardiology·Vikram Gurtu, Evangelos D Michelakis
Apr 16, 2013·The American Journal of Pathology·Angela GhatnekarMaria Trojanowska
Apr 21, 2016·Expert Review of Cardiovascular Therapy·Norbert F VoelkelMark R Nicolls
Jan 27, 2017·International Journal of Molecular Sciences·Gillian Y Moore, Graham P Pidgeon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia Cerebrovascular Disease

Basal ganglia cerebrovascular disease is a condition where the blood vessels in the basal ganglia are damaged or malfunction. Discover the latest research on basal ganglia cerebrovascular disease here.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

American Journal of Respiratory and Critical Care Medicine
R M TuderNorbert F Voelkel
The Journal of Laboratory and Clinical Medicine
R M Tuder, Norbert F Voelkel
American Journal of Respiratory and Critical Care Medicine
R M TuderNorbert F Voelkel
American Journal of Physiology. Heart and Circulatory Physiology
John E JonesYing-Yi Zhang
© 2021 Meta ULC. All rights reserved