5-Lipoxygenase and cyclooxygenase-2 in the lungs of pigs naturally affected by enzootic pneumonia and porcine pleuropneumonia

Research in Veterinary Science
R Giacominelli-StufflerMauro Maccarrone

Abstract

Enzootic pneumonia by Mycoplasma hyopneumoniae and pleuropneumonia by Actinobacillus pleuropneumoniae are among the most common and economically relevant pulmonary diseases in swine herds. We herein investigated the activity and expression of 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) in healthy and diseased porcine lungs, by means of immunohistochemical, immunochemical and biochemical assays. Diseased lungs showed a significantly higher activity and expression of 5-LOX and COX-2 in a wide range of cell types, thus suggesting the likely involvement of both enzymes in the pathogenesis of bacterial porcine pneumonia. Consistently, increased enzyme activities were paralleled by increased leukotriene B(4) (LTB(4)), a 5-LOX product and prostaglandin E(2) (PGE(2)), a COX-2 product, content in diseased versus healthy lungs.

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Citations

Apr 2, 2014·Veterinary Parasitology·Roberto Giacominelli-StufflerMauro Maccarrone
Jun 14, 2014·Journal of Comparative Pathology·M AndradaF Rodríguez
Nov 16, 2012·Research in Veterinary Science·G MarruchellaL Valbonetti
Sep 24, 2013·Therapeutic Advances in Respiratory Disease·Khanh Vinh Quoc Luong, Lan Thi Hoàng Nguyen
Aug 17, 2018·Experimental and Therapeutic Medicine·Cong FengTan-Shi Li
Apr 16, 2020·Frontiers in Veterinary Science·Marta Di FedericoCesare Cammà

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