5-S-cysteinyl-dopamine, a neurotoxic endogenous metabolite of dopamine: Implications for Parkinson's disease

Neurochemistry International
Isidro Badillo-RamírezSelva Rivas-Arancibia

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide and is characterized for being an idiopathic and multifactorial disease. Extensive research has been conducted to explain the origin of the disease, but it still remains elusive. It is well known that dopamine oxidation, through the endogenous formation of toxic metabolites, is a key process in the activation of a cascade of molecular events that leads to cellular death in the hallmark of PD. Thio-catecholamines, such as 5-S-cysteinyl-dopamine, 5-S-glutathionyl-dopamine and derived benzothiazines, are endogenous metabolites formed in the dopamine oxidative degradation pathway. Those metabolites have been shown to be highly toxic to neurons in the substantia nigra pars compacta, activating molecular mechanisms that ultimately lead to neuronal death. In this review we describe the origin, formation and the toxic effects of 5-S-cysteinyl-dopamine and its oxidative derivatives that cause death to dopaminergic neurons. Furthermore, we correlate the formation of those metabolites with the neurodegeneration progress in PD. In addition, we present the reported neuroprotective strategies of products that protect against the cellular damage of those th...Continue Reading

Citations

Dec 7, 2019·Journal of Neural Transmission·David S Goldstein
Dec 28, 2019·Journal of the American Heart Association·Anees A Banday, Mustafa F Lokhandwala
Nov 21, 2019·The Journal of Pharmacology and Experimental Therapeutics·Yunden JinsmaaDavid S Goldstein
May 20, 2021·Physical Chemistry Chemical Physics : PCCP·Isidro Badillo-RamírezDana Cialla-May
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Musbau Adewumi AkanjiOluyomi Stephen Adeyemi
Aug 15, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Saad LatifMohammad Azam Ansari

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