PMID: 6986149Jan 1, 1980Paper

5-Thiopyridoxine in rheumatoid arthritis: clinical and experimental studies

Arthritis and Rheumatism
E C HuskissonP A Dieppe

Abstract

Twelve patients with rheumatoid arthritis who had failed to respond to or developed side effects preventing further use of penicillamine were given 5-thiopyridoxine (5-TP). These patients were compared with 48 patients with similar indications randomly assigned to placebo or penicillamine. Both 5-TP and penicillamine were superior to placebo, and the effectiveness of the two active drugs was similar. Both produced a gradual amelioration of symptoms and signs of the disease accompanied by reduction in erythrocyte sedimentation rate, rheumatoid factor titer, and immunoglobulins. Nine patients on 5-TP were able to continue treatment with good control of the disease for at least 18 months. Toxic effects included rashes, proteinuria, loss of taste, and mouth ulcers. Patients who had developed a particular side effect with penicillamine did not necessarily do the same with 5-TP. This is the second mercaptan compound which has suppressive effects on the clinical and laboratory features of rheumatoid arthritis. Because of their similarities, 5-TP and penicillamine were studied in various experimental systems in an attempt to find some common biochemical or pharmacologic action. Among the properties studied were the effects on copper, v...Continue Reading

References

May 1, 1976·Rheumatology and Rehabilitation·P A DieppeT Perera
Jan 1, 1968·Annals of the Rheumatic Diseases·I A Jaffe, P Merryman
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Citations

Aug 1, 1985·Human Immunology·H StrömE Möller
Jan 1, 1983·Journal of Pharmaceutical and Biomedical Analysis·S R RudgeA J Swannell
Jan 13, 2000·International Journal of Dermatology·I GoldbergS Brenner
May 26, 1983·The New England Journal of Medicine·S S Schiffman
Oct 1, 1993·Clinics in Dermatology·S BrennerV Ruocco
Oct 31, 1983·The American Journal of Medicine·P E Lipsky
Mar 1, 1986·The American Journal of Medicine·I A Jaffe
Jan 1, 1984·Scandinavian Journal of Rheumatology·F TrottaA R Virgili
Jul 1, 1985·Medicinal Research Reviews·V J StecherD M Bailey
Jun 1, 1982·Arthritis and Rheumatism·B AmorA de Gery
Sep 1, 1988·The Journal of International Medical Research·P MastronardiB Mazzarella
Jan 6, 1986·The Medical Journal of Australia·K D Muirden

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