5-Year Outcome of Pulmonary Vein Isolation by Loss of Pace Capture on the Ablation Line Versus Electrical Circumferential Pulmonary Vein Isolation

JACC. Clinical Electrophysiology
Julia MoserDaniel Steven

Abstract

This study sought to compare long-term arrhythmia-free survival between electrical circumferential pulmonary vein isolation (PVI) and PVI with the endpoint of unexcitability along the ablation line. PVI is the standard ablation strategy of paroxysmal atrial fibrillation, although arrhythmia recurrence in long-term follow-up (FU) is high. The endpoint of unexcitability along the ablation line results in decreased arrhythmia recurrence compared to electrical PVI in 1-year FU. Seventy-four consecutive patients (age 62.5 ± 10.6 years; 70.3% male) with de novo paroxysmal atrial fibrillation who were initially included in our randomized trial and underwent catheter ablation at our institution were analyzed. Patients who were randomized to either a conventional group (PVI, guided by circumferential catheter signals) or a pace-guided group (PG, anatomical ablation line encircling, ablation until loss of pace capture at 10 V, 2-ms pulse width on the ablation line) underwent long-term FU. The primary endpoint was recurrence of any atrial fibrillation or atrial tachycardia after a blanking period of 3 months. Sixty-nine patients completed a mean FU period of 5.14 ± 0.98 years. Arrhythmia-free survival without antiarrhythmic drug therapy w...Continue Reading

References

May 18, 2007·Journal of Cardiovascular Electrophysiology·Seiichiro MatsuoSeibu Mochizuki
Feb 27, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel StevenGregory F Michaud
Jan 6, 2012·The Canadian Journal of Cardiology·Laurent MacleUNKNOWN ADVICE Study Investigators
Oct 26, 2012·The New England Journal of Medicine·Jens Cosedis NielsenPeter Steen Hansen
Nov 23, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ioanna KosmidouGregory Michaud
Oct 8, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Reza WakiliHeidi L Estner
Sep 5, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·François JourdaJean-Paul Albenque
Nov 13, 2014·Current Opinion in Cardiology·Kurt S Hoffmayer, Edward P Gerstenfeld
Jan 27, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jean-Benoît le Polain de WarouxChristophe Scavee
Jun 5, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Josef KautznerKarl-Heinz Kuck
Jun 21, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Muhammad R AfzalDhanunjaya Lakkireddy
Jul 15, 2015·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Andreas MetznerErik Wißner
Jul 18, 2015·Journal of Cardiovascular Electrophysiology·Benjamin SchaefferDaniel Steven
Sep 9, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Taihei ItohKen Okumura
Oct 16, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Arian SultanStephan Willems
Apr 5, 2016·The New England Journal of Medicine·Karl-Heinz KuckUNKNOWN FIRE AND ICE Investigators
May 14, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Waqas UllahUNKNOWN UK Multicentre Trials Group**

❮ Previous
Next ❯

Citations

Mar 4, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Benjamin SchaefferDaniel Steven

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.