5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial

Lancet
Samir R KapadiaPARTNER trial investigators

Abstract

Based on the early results of the Placement of Aortic Transcatheter Valves (PARTNER) trial, transcatheter aortic valve replacement (TAVR) is an accepted treatment for patients with severe aortic stenosis who are not suitable for surgery. However, little information is available about the late clinical outcomes in such patients. We did this randomised controlled trial at 21 experienced valve centres in Canada, Germany, and the USA. We enrolled patients with severe symptomatic inoperable aortic stenosis and randomly assigned (1:1) them to transfemoral TAVR or to standard treatment, which often included balloon aortic valvuloplasty. Patients and their treating physicians were not masked to treatment allocation. The randomisation was done centrally, and sites learned of the assignment only after a patient had been screened, consented, and entered into the database. The primary outcome of the trial was all-cause mortality at 1 year in the intention-to-treat population, here we present the prespecified findings after 5 years. This study is registered with ClinicalTrials.gov, number NCT00530894. We screened 3015 patients, of whom 358 were enrolled (mean age 83 years, Society of Thoracic Surgeons Predicted Risk of Mortality 11·7%, 54% ...Continue Reading

References

Apr 1, 1990·Journal of the American College of Cardiology·E Braunwald
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Oct 5, 2011·Circulation·Matthew R ReynoldsUNKNOWN Placement of Aortic Transcatheter Valves (PARTNER) Investigators
Mar 20, 2012·The Journal of Thoracic and Cardiovascular Surgery·D Craig MillerUNKNOWN PARTNER Stroke Substudy Writing Group and Executive Committee
Mar 27, 2012·The New England Journal of Medicine·Raj R MakkarUNKNOWN PARTNER Trial Investigators
Mar 27, 2012·The New England Journal of Medicine·Susheel K KodaliUNKNOWN PARTNER Trial Investigators
Sep 22, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kunal SarkarGian Paolo Ussia
Oct 11, 2012·Circulation. Cardiovascular Interventions·Rutger-Jan NuisPeter P de Jaegere
Nov 13, 2012·Journal of Thrombosis and Thrombolysis·Thomas PilgrimPeter Wenaweser
Nov 22, 2012·Circulation. Cardiovascular Interventions·Thomas PilgrimStephan Windecker
Mar 8, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Pamela S DouglasMartin B Leon

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Citations

Nov 17, 2015·Expert Review of Medical Devices·Esther M A WiegerinckJan Baan
Feb 13, 2016·Journal of Interventional Cardiology·Kishore J HarjaiMartin B Leon
Feb 13, 2016·Nature Reviews. Cardiology·Edward DansonRavinay Bhindi
Jan 26, 2016·Current Opinion in Cardiology·Meng-Ta TsaiGideon N Cohen
Feb 24, 2016·The Journal of Thoracic and Cardiovascular Surgery·Augusto D'OnofrioUNKNOWN Italian Transcatheter Balloon-Expandable Registry and the Sutureless Aortic Valve Implantation Research Groups
Jan 5, 2016·European Heart Journal·Bernard IungAlec Vahanian
Nov 7, 2015·Heart·Sean CoffeyBernard Iung
Oct 6, 2015·The New England Journal of Medicine·Raj R MakkarLars Søndergaard
Jan 30, 2016·Journal of the American College of Cardiology·Femi Philip
Jul 25, 2015·JACC. Cardiovascular Interventions·John G Webb, Danny Dvir
Feb 24, 2016·Der Internist·C W Hamm, T Bauer
Jan 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Darren MylottePatrick W Serruys
Feb 26, 2016·Der Internist·T ThielsenK-H Kuck
Dec 15, 2015·The Annals of Thoracic Surgery·Michael J Reardon, Neal S Kleiman
Jan 15, 2016·JACC. Cardiovascular Interventions·E Murat Tuzcu, Samir R Kapadia
May 18, 2016·Nature Reviews. Disease Primers·Brian R LindmanPhilippe Pibarot
Jan 1, 2016·JACC. Cardiovascular Interventions·Fabien PrazPeter Wenaweser
Dec 15, 2015·Journal of the American College of Cardiology·Michael J Reardon, Neal S Kleiman
May 12, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Toyoaki Murohara
Feb 26, 2016·Herz·S YücelA Öner
Jun 29, 2015·International Journal of Cardiology·Shikhar AgarwalSamir R Kapadia
Sep 19, 2015·Journal of the American College of Cardiology·Steven J YakubovUNKNOWN CoreValve United States Clinical Investigators
Apr 14, 2016·Journal of Renal Injury Prevention·Wisit CheungpasitpornKianoush Kashani
Mar 26, 2016·Journal of the American College of Cardiology·Torsten P VahlMartin B Leon
Mar 30, 2016·Current Atherosclerosis Reports·S Chris MalaisrieAndrei Churyla
Nov 26, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Walid K Abu SalehBasel Ramlawi
Sep 19, 2015·Journal of the American College of Cardiology·Thomas Pilgrim, Stephan Windecker
Jun 10, 2015·Journal of the American College of Cardiology·Ron Waksman, Augusto D Pichard
May 23, 2015·Journal of the American College of Cardiology·E Murat TuzcuLars G Svensson
Sep 19, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Bernard PrendergastStephan Windecker
Sep 19, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Antonio Colombo, Neil Ruparelia
Sep 19, 2015·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Arie Pieter Kappetein

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