5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial

Lancet
Michael J MackPARTNER 1 trial investigators

Abstract

The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that mortality at 1 year, 2 years, and 3 years is much the same with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) for high-risk patients with aortic stenosis. We report here the 5-year outcomes. We did this randomised controlled trial at 25 hospitals, in Canada (two), Germany (one), and the USA (23). We used a computer-generated randomisation sequence to randomly assign high-risk patients with severe aortic stenosis to either SAVR or TAVR with a balloon-expandable bovine pericardial tissue valve by either a transfemoral or transapical approach. Patients and their treating physicians were not masked to treatment allocation. The primary outcome of the trial was all-cause mortality in the intention-to-treat population at 1 year, we present here predefined outcomes at 5 years. The study is registered with ClinicalTrials.gov, number NCT00530894. We screened 3105 patients, of whom 699 were enrolled (348 assigned to TAVR, 351 assigned to SAVR). Overall mean Society of Thoracic Surgeons Predicted Risk of Mortality score was 11·7%. At 5 years, risk of death was 67·8% in the TAVR group compared with 62·4% in the SAVR group (ha...Continue Reading

References

Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Mar 15, 2011·Heart·Mohamed Abdel-WahabUNKNOWN German transcatheter aortic valve interventions registry investigators
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Dec 27, 2011·JACC. Cardiovascular Interventions·Oluseun O AlliDavid R Holmes
Jan 14, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Martin HaensigFriedrich Wilhelm Mohr
Mar 20, 2012·The Journal of Thoracic and Cardiovascular Surgery·D Craig MillerUNKNOWN PARTNER Stroke Substudy Writing Group and Executive Committee
Mar 27, 2012·The New England Journal of Medicine·Susheel K KodaliUNKNOWN PARTNER Trial Investigators
May 4, 2012·The New England Journal of Medicine·Martine GilardUNKNOWN FRANCE 2 Investigators
Mar 8, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Pamela S DouglasMartin B Leon
Mar 23, 2013·JACC. Cardiovascular Interventions·Ronald K BinderJohn G Webb
Aug 19, 2014·The American Journal of Cardiology·Ignacio J Amat-SantosJosep Rodés-Cabau

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Citations

Feb 16, 2016·Journal of Clinical Ultrasound : JCU·Tomo AndoCynthia C Taub
Nov 17, 2015·Expert Review of Medical Devices·Esther M A WiegerinckJan Baan
Feb 13, 2016·Journal of Interventional Cardiology·Kishore J HarjaiMartin B Leon
Feb 13, 2016·Nature Reviews. Cardiology·Edward DansonRavinay Bhindi
Feb 10, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yan-Biao LiaoMao Chen
Feb 6, 2016·JACC. Cardiovascular Imaging·Sorin V PislaruGurpreet S Sandhu
Feb 13, 2016·Journal of the American College of Cardiology·Maria Del TrigoJosep Rodés-Cabau
Feb 13, 2016·Journal of the American College of Cardiology·Michael J MackDavid R Holmes
Jan 26, 2016·Current Opinion in Cardiology·Meng-Ta TsaiGideon N Cohen
Jan 5, 2016·European Heart Journal·Bernard IungAlec Vahanian
Nov 7, 2015·Heart·Sean CoffeyBernard Iung
Feb 3, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ron Waksman
Oct 6, 2015·The New England Journal of Medicine·Raj R MakkarLars Søndergaard
Jul 25, 2015·JACC. Cardiovascular Interventions·John G Webb, Danny Dvir
Jan 21, 2016·European Heart Journal·Jeroen J BaxBernard Prendergast
Feb 26, 2016·Der Internist·T ThielsenK-H Kuck
Dec 15, 2015·The Annals of Thoracic Surgery·Michael J Reardon, Neal S Kleiman
Jan 18, 2016·The Journal of Thoracic and Cardiovascular Surgery·Ismail BouhoutDenis Bouchard
Jan 15, 2016·JACC. Cardiovascular Interventions·E Murat Tuzcu, Samir R Kapadia
Dec 24, 2015·Future Cardiology·Usaid K AllahwalaRavinay Bhindi
May 18, 2016·Nature Reviews. Disease Primers·Brian R LindmanPhilippe Pibarot
Jan 1, 2016·JACC. Cardiovascular Interventions·Fabien PrazPeter Wenaweser
Dec 15, 2015·Journal of the American College of Cardiology·Michael J Reardon, Neal S Kleiman
Mar 11, 2016·Revista Española De Cardiología·Felipe Hernández HernándezRamiro Trillo Nouche
Mar 10, 2016·The Journal of Thoracic and Cardiovascular Surgery·Jessica ForcilloVinod H Thourani
May 12, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Toyoaki Murohara
Mar 8, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Abdur Rahman KhanMichael Flaherty
Mar 8, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ehrin J ArmstrongRajan A G Patel
Feb 26, 2016·Herz·S YücelA Öner
Oct 31, 2015·Journal of the American College of Cardiology·Jean-Michel ParadisJosep Rodés-Cabau
Oct 17, 2015·Current Heart Failure Reports·Alessandro CandrevaMaurizio Taramasso
Apr 14, 2016·Journal of Renal Injury Prevention·Wisit CheungpasitpornKianoush Kashani
Oct 11, 2015·The Journal of Thoracic and Cardiovascular Surgery·Tomas A Salerno, Alexandre C Ferreira
Mar 26, 2016·Journal of the American College of Cardiology·Torsten P VahlMartin B Leon

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