500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Kullervo HynynenFerenc A Jolesz

Abstract

The aim of this study was to test a prototype MRI-compatible focused ultrasound phased array system for trans-skull brain tissue ablation. Rabbit thigh muscle and brain were sonicated with a prototype, hemispherical 500-element ultrasound phased array operating at frequencies of 700-800 kHz. An ex vivo human skull sample was placed between the array and the animal tissue. The temperature elevation during 20-30-sec sonications was monitored using MRI thermometry. The induced focal lesions were observed in T2 and contrast-enhanced T1-weighted fast spin echo images. Whole brain histology evaluation was performed after the sonications. The results showed that sharp temperature elevations can be produced both in the thigh muscle and in the brain. High-power sonications (600-1080 W) produced peak temperatures up to 55 degrees C and focal lesions that were consistent with thermal tissue damage. The lesion size was found to increase with increasing peak temperature. The device was then modified to operate in the orientation that will be used in the clinic and successfully tested in phantom experiments. As a conclusion, this study demonstrates that it is possible to create ultrasound-induced lesions in vivo through a human skull under M...Continue Reading

References

Aug 1, 1978·The Journal of the Acoustical Society of America·S A GossF Dunn
Sep 30, 1989·Lancet·R J SiegelT A DonMichael
Jan 1, 1993·European Urology·R S FosterJ P Donohue
Jan 1, 1995·Ultrasound in Medicine & Biology·C Delon-MartinD Cathignol
Jan 1, 1993·Medical Physics·K HynynenJ F Schenck
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y IshiharaY Suzuki
Jan 1, 1997·The Journal of the Acoustical Society of America·S UmemuraK Sasaki
Apr 29, 1998·Ultrasound in Medicine & Biology·K Hynynen, F A Jolesz
Sep 24, 1998·The Journal of the Acoustical Society of America·J Sun, K Hynynen
Apr 1, 1999·European Journal of Ultrasound : Official Journal of the European Federation of Societies for Ultrasound in Medicine and Biology·J Y ChapelonA Gelet
Aug 10, 1999·Journal of Magnetic Resonance Imaging : JMRI·L ChenK Butts
Feb 25, 2000·Ultrasound in Medicine & Biology·J Y ChapelonJ L Guey
Mar 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R SalomirC T Moonen
Aug 16, 2000·Ultrasound in Medicine & Biology·N VykhodtsevaK Hynynen
Dec 29, 2000·Physics in Medicine and Biology·G T ClementK Hynynen
May 8, 2001·Medical Physics·W D D'SouzaB R Thomadsen
May 7, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Greg T Clement, Kullervo Hynynen
May 28, 2002·Physics in Medicine and Biology·G T Clement, K Hynynen
Jun 25, 2002·Ultrasound in Medicine & Biology·G T Clement, Kullervo Hynynen
Dec 13, 2002·Physics in Medicine and Biology·Christopher W ConnorKullervo Hynynen
Sep 16, 1955·Science·W J FRYJ F BRENNAN
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·D R DaumK Hynynen
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·D R Daum, K Hynynen

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Citations

May 21, 2005·Pharmaceutical Research·Manabu Kinoshita, Kullervo Hynynen
Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Dani S Bidros, Michael A Vogelbaum
Feb 6, 2013·ACS Chemical Neuroscience·Alison Burgess, Kullervo Hynynen
Sep 3, 2011·Nature Protocols·Yusuf TufailWilliam J Tyler
Jan 9, 2010·Nature Reviews. Neurology·William J TylerSandipan Pati
Aug 16, 2013·The New England Journal of Medicine·W Jeffrey EliasMax Wintermark
Aug 23, 2006·Topics in Magnetic Resonance Imaging : TMRI·Wladyslaw Michal Witold Gedroyc
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·Manabu Kinoshita
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·Phillip Jason White
Apr 7, 2007·Topics in Magnetic Resonance Imaging : TMRI·Rares SalomirJean-Yves Chapelon
Jun 30, 2005·Medical Physics·Hao-Li LiuKullervo Hynynen
Oct 8, 2011·Medical Physics·Andrew B HolbrookKim Butts Pauly
Mar 8, 2011·BMC Neuroscience·Byoung-Kyong MinSeung-Schik Yoo
Oct 30, 2008·PloS One·William J TylerCassondra Majestic
Nov 7, 2013·PloS One·Martin Loynaz PrietoMerritt C Maduke
Nov 28, 2012·Journal of Neurosurgery·Stephen MonteithW Jeff Elias
Jun 15, 2007·Journal of Neurosurgery·Mathieu PernotMathias Fink
May 30, 2014·International Journal of Nanomedicine·Cui-Tao LuXin-Qiao Tian
Mar 26, 2011·Radiology·Clare M C TempanyFerenc A Jolesz
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Manabu KinoshitaKullervo Hynynen
Dec 1, 2013·The Journal of the Acoustical Society of America·Samuel RaetzBertrand Audoin
May 23, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nir LipsmanAndres M Lozano
Dec 3, 2014·Ultrasound in Medicine & Biology·Jin Woo ChangYong-Ho Lee

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