5alpha-reduced androgens may have actions in the hippocampus to enhance cognitive performance of male rats

Psychoneuroendocrinology
C A FryeJoAnna M Wawrzycki

Abstract

Androgens may improve cognitive performance; however, these effects and mechanisms of androgens are not well understood. Whether testosterone's (T) effects on cognitive performance are mediated by its 5alpha-reduced, non-aromatizable metabolite dihydrotestosterone (DHT) and/or its 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) reduced metabolite 3alpha-androstanediol (3alpha-diol), was investigated. In Experiment 1, male rats that were gonadally intact, or gonadectomized (GDX) and DHT-replaced with a silastic capsule, had better performance in the inhibitory avoidance task, and higher plasma DHT and 3alpha-diol levels, compared to GDX rats. In Experiments 2-4, intra-hippocampal indomethacin, a 3alpha-HSD inhibitor, to intact or DHT-replaced, but not GDX, rats decreased performance in the inhibitory avoidance task and reduced hippocampal 3alpha-diol levels compared to that observed in rats with control implants. Thus, the 5alpha-reduced androgen DHT has cognitive-enhancing effects, independent of E(2), which are attenuated by a 3alpha-HSD inhibitor, indomethacin. These results suggest that 5alpha-reduced androgens may have actions in the hippocampus to improve cognitive performance.

References

Sep 1, 1979·Pharmacology, Biochemistry, and Behavior·R J BodnarM Glusman
Apr 13, 1992·Neuroscience Letters·K MizoguchiT Tabira
Oct 1, 1984·Behavioral Neuroscience·T F SawyerW A Perez
Jan 1, 1995·Life Sciences·F Vázquez-PereyraS Schneider-Rivas
Dec 1, 1994·Molecular and Cellular Neurosciences·N J MacLuskyC D Toran-Allerand
Nov 1, 1994·Behavioral and Neural Biology·V Luine, M Rodriguez
Jan 31, 1994·Neuroreport·A BruscoJ Pecci Saavedra
Apr 1, 1994·Behavioral Neuroscience·J S JanowskyE S Orwoll
Aug 8, 1998·Psychoneuroendocrinology·C A Frye, T A Reed
Oct 10, 1998·The American Journal of Psychiatry·H Sternbach
Feb 25, 2000·The Journal of Urology·A MoralesC C Carson
Aug 10, 2000·Journal of Cognitive Neuroscience·J S JanowskyE Orwoll
Mar 13, 2001·Hormones and Behavior·M F KritzerJ K Robinson
Jan 5, 2002·Learning & Memory·T W BuchananR Adolphs
Jan 12, 2002·Hormone Research·S Howell, S Shalet
Jun 7, 2002·Behavioral Neuroscience·Donna L Korol, Lacy L Kolo
Dec 7, 2002·Cognitive, Affective & Behavioral Neuroscience·C A Frye, A M Seliga

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Citations

Jul 13, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cheryl A FryeKanako Sumida
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mary F Kritzer, Lela M Creutz
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vanessa A SkucasHelen E Scharfman
Feb 14, 2007·Experimental and Clinical Psychopharmacology·Stuart T LeonardPeter J Winsauer
Jan 24, 2012·Hormones and Behavior·Sarah E A McConnellJanice E Thornton
Jan 3, 2012·Behavioural Brain Research·Tina KhorshidahmadMohammad Sharifzadeh
Nov 4, 2015·Journal of Toxicology and Environmental Health. Part a·Jia Jian-XinZhan-Jun Yang
Apr 12, 2008·Hormones and Behavior·Sara SarkeyLydia L DonCarlos
May 1, 2007·Neuroscience Research·Misael Alejandre-GomezIgnacio Gonzalez-Burgos
Jan 29, 2005·Annals of the New York Academy of Sciences·A G Alias
Jan 29, 2005·Annals of the New York Academy of Sciences·R O GoyalA G Alias
Jul 31, 2008·Cancer·Christian J NelsonAndrew J Roth
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Kassandra L Edinger
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye, Alicia A Walf
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Kassandra L EdingerCheryl A Frye
Aug 15, 2006·Neurobiology of Learning and Memory·Kassandra L Edinger, Cheryl A Frye
Apr 18, 2015·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·N WestlundJ L Bird
Sep 7, 2016·Journal of Toxicology and Environmental Health. Part a·Jian-Xin JiaZhan-Jun Yang
Sep 18, 2008·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Zoë G HodgsonSusan D Healy
Jun 29, 2006·The Journal of Biological Chemistry·Manuel EstradaBarbara E Ehrlich
Feb 8, 2020·Biomolecules·Mark D Spritzer, Ethan A Roy
Apr 9, 2020·Frontiers in Neuroscience·Amy Stave Kohtz, Cheryl A Frye
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caitlin A OrsiniBarry Setlow

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