5Alpha-reductase inhibition activity of steroids isolated from marine soft corals

Steroids
P RadhikaG García

Abstract

The aim of this study is to determine the 5alpha-reductase inhibitory activity of several new steroidal compounds PR-01-PR-07 by measuring the conversion of [3H]T to[3H]DHT in Penicillium crustosum broths. These compounds were obtained from marine soft corals collected on the coasts of Andaman and Nicobar at Hori, Natkal and Kalipur (Diglipur) Islands and identified as Sinularia grandilobata Verseveldt, Sinularia crassa Tixier- Durivault, Sinularia gravis Tixier- Durivault, Sinularia sp., Lobophytum sp., Lobophytum crassum and Cladiella sp. PR-01-PR-04 significantly inhibited the conversion of [3H]T to [3H]DHT (P < 0.05) whereas PR-05 and PR-06 did not show an appreciable difference (P > 0.05) in this model. On the other hand PR-07 stimulated (P < 0.05) the enzymatic reaction.

References

Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·M KriegS Tunn
Sep 19, 2000·Chemical & Pharmaceutical Bulletin·E A BratoeffM Cabeza
Feb 7, 2003·Mini Reviews in Medicinal Chemistry·Eugenio FloresIvonne Heuze

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Citations

Feb 5, 2014·Chemical & Pharmaceutical Bulletin·Nguyen Xuan CuongChau Van Minh
Nov 11, 2011·Marine Drugs·Chih-Hua ChaoJyh-Horng Sheu
Mar 14, 2012·Marine Drugs·Chih-Hua ChaoJyh-Horng Sheu
Feb 3, 2006·Natural Product Reports·John W BluntMichèle R Prinsep
Dec 3, 2015·Organic & Biomolecular Chemistry·Marie Pascaline RahelivaoHans-Joachim Knölker
Feb 3, 2006·Natural Product Reports·James R Hanson
Jun 4, 2016·Bioorganic & Medicinal Chemistry Letters·Wan-Ru TsengJyh-Horng Sheu
May 10, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun-Sheng LinJui-Hsin Su
May 14, 2009·Chemical Reviews·Nittala S SarmaP S Parameswaran

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