5alpha-reductase inhibitory components as antiandrogens from herbal medicine

Journal of Acupuncture and Meridian Studies
Chul-Ho ChoYong-ung Kim

Abstract

We investigated medicinal plant sources with 5alpha-reductase inhibitory activity. These compounds have been used in several remedies against androgen-dependent diseases including benign prostatic hyperplasia. The 50% ethanol extract of Polygonum multiflorum Thunb (Polygoni Multiflori Radix; Polygonaceae) showed potent 5alpha-reductase inhibitory activity. The fraction responsible for this activity was purified, and the active constituent was isolated and identified as emodin, an anthraquinone compound. Although emodin showed considerably less potent inhibitory activity than riboflavin, the inhibitory activity of the compound was more potent than that of alizarin (1,2-dihydroxyanthraquinone), an anthraquinone-type positive control. Also, anthraquinone itself was substantially inactive against 5alpha-reductase, in dicating that the hydroxyl group on the structure of emodin is an important structural moiety for displaying inhibitory activity.

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Citations

May 31, 2014·Expert Opinion on Therapeutic Targets·Ruchy Jain, Wanchai De-Eknamkul
May 27, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ruchy JainWanchai De-Eknamkul
Dec 24, 2018·Assay and Drug Development Technologies·Jukkarin SrivilaiKornkanok Ingkaninan
Jul 27, 2021·Phytochemistry·Ruchi Badoni SemwalAlvaro Viljoen

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