PMID: 9541145Apr 16, 1998Paper

5HT2C CYS23/SER23 polymorphism is not associated with obsessive-compulsive disorder

Psychiatry Research
Maria Cristina CavalliniLaura Bellodi

Abstract

A great deal of evidence suggests that a genetic component underlies obsessive-compulsive disorder (OCD). The response to serotonergic medications and the worsening of obsessive symptoms after administration of serotonergic agonists indicate that serotonergic mechanisms are involved in OCD. We investigated the role of the Cys23Ser mutation of the 5HT2C receptor gene in the etiology of this disorder by performing an association study comparing a sample of 109 OCD patients with a sample of 107 healthy control subjects. No allelic or genotypic association of OCD with the 5HT2C receptor gene mutation was revealed in our data. We also extended the association analysis to a subsample of 39 OCD patients that had previously been submitted to a challenge test with clomipramine. In the subsample of OCD patients that received the challenge with clomipramine, no association between the 5HT2C receptor gene mutation and response to the challenge test was found. Our results exclude any specific role of the Cys23Ser mutation of 5HT2C receptor gene in the etiology of OCD: it seems probable that more complex genetic models are needed to explain the involvement of serotonergic elements in the etiology of this disorder.

References

May 11, 1992·Archives of General Psychiatry·D W BlackN Blum
Sep 1, 1991·Biological Psychiatry·S W KimJ M Davis
Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Jul 1, 1990·Psychiatry Research·J F LeckmanG M Anderson
Apr 15, 1991·Biological Psychiatry·G L HannaD P Cantwell
Aug 1, 1990·Psychological Medicine·J L Rapoport
Nov 1, 1985·Biological Psychiatry·T R InselD L Murphy
Nov 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Feb 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J F LeckmanD L Pauls
Jan 1, 1995·The American Journal of Psychiatry·D L PaulsJ F Leckman
Jan 1, 1993·Psychosomatics·S L Rauch, M A Jenike
Sep 13, 1996·Science·N Risch, K Merikangas
Dec 18, 1995·American Journal of Medical Genetics·G SciutoL Bellodi

❮ Previous
Next ❯

Citations

Apr 5, 2005·Depression and Anxiety·Helen Blair SimpsonMichael R Liebowitz
Dec 21, 2000·Current Psychiatry Reports·D J SteinS L Rauch
Mar 29, 2001·Current Psychiatry Reports·M T PatoC N Pato
Apr 12, 2000·Journal of Psychiatric Research·A SerrettiE Smeraldi
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brian H HarveyDan J Stein
May 4, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A FrischR Weizman
May 16, 2001·American Journal of Medical Genetics·I MuradR P Ebstein
Feb 18, 2010·The Psychiatric Clinics of North America·Gerald NestadtJack F Samuels
May 3, 2006·The Psychiatric Clinics of North America·Sîan M J Hemmings, Dan J Stein
Jun 1, 1999·Acta Neuropsychiatrica·B J van de WeteringD L Pauls
Jun 1, 2011·Arquivos de neuro-psiquiatria·Karen MiguitaHomero Vallada
Mar 29, 2002·American Journal of Medical Genetics·Maria Cristina CavalliniLaura Bellodi
Feb 13, 2002·American Journal of Medical Genetics·John P AlsobrookDavid L Pauls
Dec 24, 2002·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Bruno MilletMarie-Odile Krebs
Feb 9, 2006·The American Journal of Gastroenterology·Christopher E CamilleriRaul Urrutia
Jan 17, 2008·Psychiatric Genetics·Jens R WendlandDennis L Murphy
Jun 26, 2002·The Pharmacogenomics Journal·D Di BellaL Bellodi
Aug 7, 2007·Expert Review of Neurotherapeutics·Marco Grados, Holly C Wilcox
Aug 31, 2006·Yonsei Medical Journal·Se Joo Kim, Chan-Hyung Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.