PMID: 2498925Jan 1, 1989Paper

5HT3 receptor antagonists block morphine- and nicotine- but not amphetamine-induced reward

Psychopharmacology
E CarboniG Di Chiara

Abstract

The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Drug-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.

References

Feb 1, 1985·Pharmacology, Biochemistry, and Behavior·P J FudalaE T Iwamoto
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Dec 16, 1986·European Journal of Pharmacology·A ImperatoG Di Chiara
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Citations

Jan 1, 1991·Psychopharmacology·K A TrujilloL Stein
May 1, 1995·Psychopharmacology·B ArnoldA J Greenshaw
Mar 15, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Jun 23, 2009·Cellular and Molecular Neurobiology·Anna M S Kindlundh-HögbergAsa Fex Svenningsen
May 30, 1989·European Journal of Pharmacology·E CarboniG Di Chiara
Sep 21, 1990·European Journal of Pharmacology·M E Reith
Aug 14, 1992·European Journal of Pharmacology·N R NewberryD G Grahame-Smith
Jun 6, 1995·European Journal of Pharmacology·M D SchechterJ B Schechter
Aug 8, 1996·European Journal of Pharmacology·R StefanskiW Kostowski
Aug 1, 1993·Neuropharmacology·N R NewberryR A Leslie
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·M D Schechter
Apr 1, 1992·Pharmacology, Biochemistry, and Behavior·M D Schechter, S M Meehan
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·A L Svingos, R Hitzemann
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·A M Davies, L A Parker
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·J P ZacnyJ G Zaragoza
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·F O Risinger, R A Oakes
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·A D Campbell, W J McBride
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·L A Parker, K Doucet
Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·R De La GarzaK A Cunningham
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·M T BardoM J Harris
Sep 1, 1990·Journal of Neuroscience Methods·G Di Chiara
Jul 1, 1995·Neuroscience Research·R E SteinpreisM C Piwowarczyk
Sep 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·D J Calcagnetti, M D Schechter

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