PMID: 3772747Aug 1, 1986Paper

6 alpha-Methylprednisolone and 6 alpha-methylprednisone plasma protein binding in humans and rabbits

Journal of Pharmaceutical Sciences
W F EblingW J Jusko

Abstract

The binding of 6 alpha-methylprednisolone and 6 alpha-methylprednisone to proteins of rabbit and human plasma was studied in vitro by equilibrium dialysis. Steroid binding was determined using radiolabeled compounds and HPLC analysis methods. Both methods produced equivalent results. Plasma protein binding of 6 alpha-methylprednisolone and 6 alpha-methylprednisone averaged 75-82% and was independent of steroid concentration, suggestive of low affinity, nonspecific protein binding. A positive linear correlation of the log octanol-water partition coefficient with the nonspecific binding affinities of a homologous series of steroids, including 6 alpha-methylprednisolone and 6 alpha-methylprednisone, was demonstrated. This correlation suggests that hydrophobic binding is a major determinant of nonspecific steroid-protein interactions.

References

Jan 1, 1979·Monographs on Endocrinology·P L Ballard
Jun 1, 1984·Journal of Pharmaceutical Sciences·F D Boudinot, W J Jusko
Sep 1, 1984·Journal of Steroid Biochemistry·F D Boudinot, W J Jusko
Jul 1, 1983·Journal of Steroid Biochemistry·U Westphal
Jan 1, 1982·Journal of Steroid Biochemistry·R V TomlinsonN Chu
Nov 1, 1981·Journal of Pharmaceutical Sciences·M L Rocci, W J Jusko
Aug 1, 1981·Journal of Pharmacokinetics and Biopharmaceutics·J Q RoseW J Jusko

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Citations

Jan 1, 1986·European Journal of Clinical Pharmacology·S J SzeflerW J Jusko
Jan 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·W F EblingW J Jusko
Feb 8, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Anasuya HazraWilliam J Jusko
Sep 1, 1991·The American Review of Respiratory Disease·L S GreosM R Hill
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Oct 1, 1988·The Journal of Pharmacy and Pharmacology·K Walter, H Kurz
Jun 9, 1999·The Journal of Allergy and Clinical Immunology·D A FostJ D Spahn
Jul 17, 2007·Journal of Pharmaceutical and Biomedical Analysis·Rajendra N GoyalNeeta Bachheti
Feb 19, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Shaun D CooperThomas W Hale
Mar 4, 2020·Pharmacological Reviews·Vivaswath S Ayyar, William J Jusko
Jun 15, 2019·The Journal of Pharmacology and Experimental Therapeutics·Vivaswath S AyyarWilliam J Jusko
Nov 10, 2006·Advanced Drug Delivery Reviews·Donald E Mager
Oct 1, 1989·Journal of Pharmaceutical Sciences·G L JungbluthW J Jusko
Feb 1, 1992·Journal of Pharmaceutical Sciences·D B Haughey, W J Jusko

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