PMID: 8953681Jan 1, 1996Paper

6-day amoxicillin versus 10-day penicillin V for group A beta-haemolytic streptococcal acute tonsillitis in adults: a French multicentre, open-label, randomized study. The French Study Group Clamorange

Scandinavian Journal of Infectious Diseases
D PeyramondR Cohen

Abstract

We compared the efficacy and safety of amoxicillin 1 g b.i.d. for 6 days and penicillin V 1 MU t.i.d. for 10 days in the treatment of group A beta-haemolytic streptococcal (GABHS) tonsillitis in adults. 342 patients with acute tonsillitis and a positive test for streptococcal antigen were included in a multicentre, randomized, open-label study; 338 patients were evaluable in an intention-to-treat analysis, and 234 with a positive throat swab culture in a per-protocol analysis. In the per-protocol analysis, the GABHS eradication rate at the end of treatment was comparable in the two groups: 92% (115/125) on amoxicillin and 92.7% (101/109) on penicillin (p = 0.95), as were the clinical success rates of 96% and 95.4%, respectively (p = 0.92). At the follow-up visit (day 28-32), 90.8% of patients treated with amoxicillin and 92.6% of those treated with penicillin V were free of GABHS (p = 0.85). Sore throat disappeared significantly faster on day 2 (p = 0.039) in the amoxicillin group. The intention-to-treat analysis gave similar clinical results. Tolerability was good in both groups. The efficacy and safety of amoxicillin 1 g b.i.d. for 6 days were not statistically different from those of penicillin V 1 MU t.i.d. for 10 days in t...Continue Reading

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Citations

Jul 1, 1997·The Pediatric Infectious Disease Journal·M E Pichichero, R Cohen
Sep 23, 2000·The Pediatric Infectious Disease Journal·M E Pichichero
Oct 13, 2005·The Pediatric Infectious Disease Journal·Janet R Casey, Michael E Pichichero
Dec 23, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·UNKNOWN Agence Française de Sécurité Sanitaire des Produits de Santé
Mar 11, 2017·Médecine et maladies infectieuses·C WintenbergerUNKNOWN Recommendation Group of the SPILF
Nov 7, 2003·Clinical Pediatrics·Stan L Block
Jan 5, 2018·Infection & chemotherapy·Young Kyung YoonShin Woo Kim
Aug 4, 2001·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·H PortierUNKNOWN Groupe d'étude de pathologie infectieuse pédiatrique

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