6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells

Journal of Natural Products
Chung-Yi ChenSoong-Yu Kuo

Abstract

[6]-gingerol, a major phenolic compound derived from ginger (Zingiber officinale), is a potential chemopreventive compound that can induce stress in cancer cells and cause apoptotic cell death. This study examines the early signaling effects of [6]-gingerol on renal cells. It was found that [6]-gingerol caused a slow and sustained rise of [Ca2+]i in a concentration-dependent manner. [6]-gingerol also induced a [Ca2+]i rise when extracellular Ca2+ was removed, but the magnitude was reduced by 80%. Depletion of intracellular Ca2+ stores with CCCP, a mitochondrial uncoupler, did not affect the action of [6]-gingerol. In a Ca2+-free medium, the [6]-gingerol-induced [Ca2+]i rise was partially abolished by depleting stored Ca2+ with thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor). The elevation of [6]-gingerol-caused [Ca2+]i in a Ca2+-containing medium was not affected by modulation of protein kinase C activity. The [6]-gingerol-induced Ca2+ influx was blocked by nicardipine. U73122, an inhibitor of phospholipase C, abolished ATP (but not [6]-gingerol)-induced [Ca2+]i rise. These findings suggest that [6]-gingerol induces a significant rise in [Ca2+]i in MDCK renal tubular cells by stimulating both extracellular Ca2+ infl...Continue Reading

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Citations

Jan 18, 2011·Natural Product Research·Chung-Yi Chen, Yu-Ting Yeh
Nov 15, 2011·Natural Product Research·Soong-Yu KuoChung-Yi Chen
Oct 16, 2012·American Journal of Respiratory Cell and Molecular Biology·Elizabeth A TownsendCharles W Emala
Mar 4, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chung-Yi ChenSoong-Yu Kuo
Aug 21, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Hong LiBasil D Roufogalis
Jul 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ahmed S IbrahimFarid A Badria
Sep 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chi-Ming LiuChung-Yi Chen
Aug 1, 2015·Phytochemistry·Ruchi Badoni SemwalAlvaro M Viljoen
Jul 31, 2010·Journal of Natural Products·Chung-Yi ChenSoong-Yu Kuo
Nov 21, 2012·Journal of Natural Products·Chung-Ren JanSoong-Yu Kuo
Jun 27, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ching-Hsein ChenSoong-Yu Kuo

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