6-hydroximino-4-aza-A-homo-cholest-3-one and related analogue as a potent inducer of apoptosis in cancer cells

Steroids
Yanmin HuangAimin Zhou

Abstract

Here we report that 6-hydroximino-4-aza-A-homo-cholest-3-one and 6-hydroxyl-4-aza-A-homo-cholest-3-one, new steroidal lactams were synthesized recently, displayed antiproliferative activity against some cancer cells through inducing cancer cell apoptosis by activation of the intrinsic pathway. The apoptotic function of the compounds was demonstrated by release of cytochrome C, activation of caspase 3 and annexin V labeling. Furthermore, the compound was able to inhibit tumor growth in an athymic mouse model.

References

Dec 2, 2005·Breast Cancer Research and Treatment·Dimitrios T P TrafalisCharalambos Camoutsis
Apr 17, 2007·Steroids·Natalija M KrstićVladimir D Pavlović
Mar 21, 2008·Bioorganic & Medicinal Chemistry·Anna I KoutsoureaSotiris S Nikolaropoulos
May 19, 2009·European Journal of Medicinal Chemistry·Mohamed El-FarMohamed A Tantawy
May 17, 2011·Bioorganic & Medicinal Chemistry Letters·Yanmin HuangHuacan Song
Jul 20, 2011·Steroids·Yanmin HuangAimin Zhou

❮ Previous
Next ❯

Citations

Dec 10, 2013·Steroids·Hua-Xin Zhang, Y Liu
Jun 28, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yanmin HuangAimin Zhou
Aug 24, 2021·Bioorganic & Medicinal Chemistry·Ana R GomesFernanda M F Roleira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis