6-Hydroxydopamine lesion of the rat prefrontal cortex increases locomotor activity, impairs acquisition of delayed alternation tasks, but does not affect uninterrupted tasks in the radial maze

Behavioural Brain Research
M Bubser, W J Schmidt

Abstract

The role of mesocortical dopamine neurons in locomotion and acquisition of various delayed and uninterrupted maze tasks was investigated in the rat. Dopaminergic terminals of the medial prefrontal cortex were lesioned by stereotaxically guided injections of the selective neurotoxin 6-hydroxydopamine (6-OHDA), while noradrenergic neurons were protected by systemically administered desipramine. 6-OHDA lesions resulted in a selective depletion of dopamine and its metabolite, dihydroxyphenylacetic acid, in the prefrontal cortex but not in subcortical structures. Prefrontal serotonin was not depleted. 6-OHDA-cloned rats performed uninterrupted alternation tasks (spontaneous and reinforced alternation) in the radial maze in the same manner as controls, whereas performance of delayed alternation in the T-maze and the radial maze was impaired in lesioned rats. In addition, locomotor activity during maze performance was increased in lesioned rats. Based on the hypothesis that increased motor activity and impaired delayed alternation performance are due to increased susceptibility to interfering stimuli, we propose tentatively that prefrontal dopamine may function to suppress interference during the delay period of certain cognitive tasks.

References

Jan 1, 1979·Journal of Neuroscience Research·K Biziere, J T Coyle
Jan 15, 1977·The Journal of Comparative Neurology·J E Krettek, J L Price
Jan 1, 1988·Trends in Neurosciences·M SarterD N Stephens
Jan 1, 1989·Journal of Neural Transmission. General Section·W Hauber, W J Schmidt
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·E D Levin
Jan 1, 1988·Experimental Brain Research·T KlockgetherK H Sontag
Jan 1, 1987·Physiology & Behavior·D J McCannJ C Winter
Mar 1, 1974·Physiology & Behavior·B Kolb
Nov 2, 1973·Science·A M ThierryJ Glowinski
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Jan 1, 1980·Experimental Brain Research·H J MarkowitschB Petrović-Minić
Nov 3, 1980·Brain Research·J T BeckerD S Olton
Sep 1, 1980·Pharmacology, Biochemistry, and Behavior·T G HeffnerL S Seiden

❮ Previous
Next ❯

Citations

Oct 1, 1993·Annals of Neurology·R TomerW J Weiner
Dec 25, 2004·Psychopharmacology·Judit LaszyIstván Gyertyán
May 4, 2006·Psychopharmacology·Stan B Floresco, Orsolya Magyar
Aug 24, 2012·Journal of Neural Transmission·Joseph A Schwartz, Kevin M Beaver
Jun 1, 1995·Physiology & Behavior·S Sudha, N Pradhan
Mar 31, 1993·Behavioural Brain Research·C Shaw, J P Aggleton
Jun 1, 1991·Brain Research Bulletin·T R GuilarteT H Moran
Mar 1, 1992·Neurotoxicology and Teratology·E D LevinR E Bowman
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M KurachiY Sakurai
Mar 1, 1995·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Y SakuraiM Kurachi
Jan 23, 1999·Biological Psychiatry·J I FriedmanK L Davis
Jun 6, 2002·Behavioural Brain Research·Laurent LacroixJoram Feldon
Apr 15, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Philip M WallD Caroline Blanchard
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
May 5, 1998·Brain Research Bulletin·H TanilaP Riekkinen
Oct 10, 2002·Neural Networks : the Official Journal of the International Neural Network Society·Jean-Claude Dreher, Yves Burnod

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.