PMID: 8949645Sep 1, 1996Paper

6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity

Gut
C CuffariG Seidman

Abstract

6-Mercaptopurine (6-MP) has confirmed short and longterm efficacy in the treatment of IBD. However, the relation between its metabolism, efficacy, and side effects is not well understood. To assay 6-MP metabolites and to correlate levels with drug compliance, disease activity, and adverse effects of treatment. Heparinised blood was obtained prior to daily administration of 6-MP in 25 adolescent Crohn's disease patients (14 ileocolitis, 11 colitis) receiving 1.2 (range 0.4-1.6) mg/kg/day for a mean of 17 (range 4-65) months. Erythrocyte free bases 6-thioguanine (6-TG) and 6-methyl-mercaptopurine (6-MMP) were measured (pmol/8 x 10(8) red blood cells) using reverse phase high performance liquid chromatography. Disease activity (modified Harvey-Bradshaw index) improved significantly with 6-MP (p = 0.001). Clinical remission was achieved in 72% of patients, who stopped taking prednisone, or were successfully weaned to a low alternate day dose (< 0.4 mg/kg/OD). Remission correlated well with erythrocyte 6-TG (p < 0.05), but not 6-MMP levels. Neutropenia was associated with 6-MP use (p < 0.005), but did not correlate with erythrocyte 6-MP metabolite levels. One patient refractory to 6-MP had 6-TG, but no measureable 6-MMP production, ...Continue Reading

References

Jan 1, 1992·European Journal of Clinical Pharmacology·L Lennard
May 1, 1991·Mayo Clinic Proceedings·J PerraultW J Tremaine
Nov 1, 1990·Gastroenterology·J MarkowitzF Daum
Jul 1, 1991·Gastroenterology·J J O'BrienJ A Bayless
Nov 1, 1990·The Journal of Pediatrics·M VerhaveR J Grand
Dec 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L Lennard, J S Lilleyman
Aug 1, 1989·Clinical Pharmacology and Therapeutics·L LennardR M Weinshilboum
Oct 15, 1989·Annals of Internal Medicine·D H PresentB I Korelitz
May 1, 1985·Journal of Clinical Immunology·M BroganS Targan
Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Oct 1, 1983·British Journal of Clinical Pharmacology·L LennardJ L Maddocks
Apr 6, 1993·Biochemical Pharmacology·J P BökkerinkJ A van Baal
Nov 4, 1994·Journal of Chromatography. B, Biomedical Applications·L Lennard, H J Singleton
Aug 1, 1993·The American Journal of Gastroenterology·B I KorelitzA L Sacknoff

❮ Previous
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Citations

Apr 25, 2007·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Feb 2, 2008·Inflammatory Bowel Diseases·Dorota WalkiewiczSubra Kugathasan
Sep 26, 2008·Inflammatory Bowel Diseases·Burton I Korelitz
Mar 4, 2010·Inflammatory Bowel Diseases·Udayakumar Navaneethan, Bo Shen
Feb 16, 2010·Inflammatory Bowel Diseases·B JharapA A van Bodegraven
Jun 15, 2006·Digestive Diseases and Sciences·Albert J Czaja, Herschel A Carpenter
Nov 18, 2000·Current Gastroenterology Reports·W J Sandborn, W A Faubion
Aug 25, 2000·Current Gastroenterology Reports·E G Seidman
May 3, 2003·The Israel Medical Association Journal : IMAJ·Alexandra LavyUNKNOWN Israel gastroenterology association
Mar 15, 2006·Current Gastroenterology Reports·Luc J J Derijks, Daniel W Hommes
Aug 14, 2010·World Journal of Pediatrics : WJP·Carmen Cuffari
Jul 10, 2003·Gastroenterology·Raymond C Givens, Paul B Watkins
Feb 24, 2001·The Surgical Clinics of North America·R B Stein, G R Lichtenstein
Jun 18, 1999·Gastroenterology Clinics of North America·R B Stein, S B Hanauer
Jul 30, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M ChrzanowskaJ Fiet
Jan 16, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ian D R ArnottJack Satsangi
May 1, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Carmen CuffariTheodore M Bayless
Sep 9, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marla C Dubinsky
Nov 1, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C G SuG R Lichtenstein
Feb 9, 2012·Nature Reviews. Gastroenterology & Hepatology·Michael Camilleri
Sep 27, 2006·The Pharmacogenomics Journal·R L RobertsM A Kennedy
May 29, 2002·Alimentary Pharmacology & Therapeutics·A BarabinoC Barbera
Dec 21, 2002·Alimentary Pharmacology & Therapeutics·R S Bloomfeld, J E Onken
Feb 1, 2004·Clinics in Colon and Rectal Surgery·Uma Mahadevan
Oct 7, 2006·Current Opinion in Gastroenterology·S B Hanauer
Dec 29, 2000·Journal of Clinical Gastroenterology·M D Regueiro
Sep 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·C DeslandresE G Seidman
Jan 16, 1999·Journal of Pediatric Gastroenterology and Nutrition·C Cuffari, A Lake
Nov 8, 2001·Journal of Pediatric Gastroenterology and Nutrition·P GuptaB S Kirschner
Sep 28, 2002·Journal of Pediatric Gastroenterology and Nutrition·Carolina RumboBenjamin L Shneider
Feb 21, 2004·Journal of Pediatric Gastroenterology and Nutrition·Thomas R Walker, Alan M Leichter
May 25, 1999·Inflammatory Bowel Diseases·S Kane
Jun 1, 2004·Inflammatory Bowel Diseases·William J Sandborn

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