6-Methoxyluteolin from Chrysanthemum zawadskii var. latilobum suppresses histamine release and calcium influx via down-regulation of FcεRI α chain expression

Journal of Microbiology and Biotechnology
Sun-Yup ShimDae-Seok Byun

Abstract

Mast cells and basophils are important effector cells in immunoglobulin-E (IgE)-mediated allergic reactions. Using the human basophilic KU812F cells, we assessed the inhibitory effects of 6-methoxyluteolin, isolated from Chrysanthemum zawadskii, in the FcεRI-mediated allergic reaction. We determined that 6-methoxyluteolin inhibited anti-FcεRI α chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Moreover, the inhibitory effects of 6-methoxyluteolin on the cell surface expression and the mRNA level of the FcεRI α chain were determined by flow cytometric analysis and reverse transcription-polymerase chain reaction (RTPCR), respectively. Therefore, these results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcεRI α chain.

Citations

Sep 18, 2015·Journal of Neuroinflammation·Stavros PolyzoidisTheoharis C Theoharides
Sep 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pelin TastanJudit Hohmann
Dec 17, 2014·The Journal of Allergy and Clinical Immunology·Zuyi WengTheoharis C Theoharides
Jan 28, 2015·Journal of Agricultural and Food Chemistry·Lie-Chwen LinTung-Hu Tsai
Feb 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xi ChenXuan Li

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