Abstract
6'-O-galloylpaeoniflorin (GPF), a galloylated derivative of paeoniflorin isolated from peony root, has been proven to possess antioxidant potential. In this present study, we revealed that GPF treatment exerted significant neuroprotection of PC12 cells following OGD, as evidenced by a reduction of oxidative stress, inflammatory response, cellular injury, and apoptosis in vitro. Furthermore, treatment with GPF increased the levels of phosphorylated Akt (p-Akt) and nuclear factor-erythroid 2-related factor 2 (Nrf2), as well as promoted Nrf2 translocation in PC12 cells, which could be inhibited by Ly294002, an inhibitor of phosphoinositide 3-kinase (PI3K). In addition, Nrf2 knockdown or Ly294002 treatment significantly attenuated the antioxidant, anti-inflammatory, and antiapoptotic activities of GPF in vitro. In vivo studies indicated that GPF treatment significantly reduced infarct volume and improved neurological deficits in rats subjected to CIRI, as well as decreased oxidative stress, inflammation, and apoptosis, which could be inhibited by administration of Ly294002. In conclusion, these results revealed that GPF possesses neuroprotective effects against oxidative stress, inflammation, and apoptosis after ischemia-reperfusio...Continue Reading
References
Mar 1, 1991·Archives of Pharmacal Research·S S KangH J Chi
Mar 8, 2000·Biological & Pharmaceutical Bulletin·T OkuboI Kano
Feb 24, 2001·Chemical & Pharmaceutical Bulletin·H MatsudaM Yoshikawa
Apr 18, 2003·American Journal of Physiology. Cell Physiology·Satoshi NumazawaTakemi Yoshida
Oct 8, 2003·Current Pharmaceutical Design·M J AlcarazM I Guillén
Nov 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andy Y ShihTimothy H Murphy
May 18, 2007·Neuroscience·Z A ShahS Doré
Apr 4, 2008·Investigative Ophthalmology & Visual Science·Ling WangJiyang Cai
Aug 12, 2009·PloS One·Zheng SunDonna D Zhang
Aug 13, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark KristiansenJonathan Ham
Nov 16, 2010·Brain Research·Nobuhito TanakaKoji Abe
Jan 5, 2011·Antioxidants & Redox Signaling·Regina Brigelius-Flohé, Leopold Flohé
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Candy S LeeJefferson Y Chan
Mar 29, 2013·Hippocampus·Ruimin WangFang Yang
Jul 31, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hiroyuki MuramatsuMasayuki Yamamoto
Aug 1, 2013·Cerebrovascular Diseases·P AmarencoM G Hennerici
Nov 19, 2013·Biomolecules & Therapeutics·Cheng Wen YaoJin Won Hyun
Jan 1, 2014·Current Medicinal Chemistry·J Y KimM A Yenari
Apr 2, 2014·In Vitro Cellular & Developmental Biology. Animal·Cheng Wen YaoJin Won Hyun
Nov 5, 2012·Neural Regeneration Research·Fengzhang WangQun Liu
Nov 19, 2014·Frontiers in Cellular Neuroscience·Anna Carolina Carvalho da FonsecaFlavia Regina Souza Lima
Dec 4, 2014·PloS One·Hong PanMingliang Pu
Apr 22, 2015·International Journal of Biological Sciences·Huiqing LiuLin Chen
Aug 8, 2015·Drug Design, Development and Therapy·Ashok Kumar PanduranganChung Yeng Looi
Aug 14, 2015·Phytotherapy Research : PTR·Zhe ChenXiaohe Xiao
Jan 19, 2016·Molecular Neurobiology·Chao GuoAidong Wen
Feb 5, 2016·Journal of Molecular Neuroscience : MN·Jing Sun, Guangxian Nan
Mar 17, 2016·Journal of Ethnopharmacology·Xinwei YangLiping Xu
Apr 22, 2016·Cellular and Molecular Life Sciences : CMLS·Agnieszka LobodaJozef Dulak
Jun 14, 2016·JCI Insight·Sean X GuSteven R Lentz
Jan 18, 2017·Neuropsychiatric Disease and Treatment·Xuezheng Fan, Linshen Mu
Feb 6, 2017·Circulation Research·Valery L FeiginGeorge A Mensah
Mar 23, 2017·Journal of the Neurological Sciences·Pramila Bakthavachalam, Prakash Srinivasan Timiri Shanmugam
Apr 13, 2017·Molecular Neurobiology·Anthony R AnzellThomas H Sanderson
May 17, 2017·Biophysics Reviews·Prashant DeshmukhBalasundaram Padmanabhan
May 30, 2017·Trends in Pharmacological Sciences·Patrik PopracMarian Valko
Citations
Jan 1, 2019·Cardiovascular Therapeutics·Qing LiuYing Zhang
Jul 18, 2020·Journal of Cellular and Molecular Medicine·Chaoliang TangXiaoqing Chai
Aug 14, 2020·Neural Regeneration Research·Han-A ParkElizabeth A Jonas
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Meiyu JinGuowen Liu
Jul 28, 2020·Frontiers in Molecular Neuroscience·Md Abdul HannanIl Soo Moon
Jan 22, 2019·Frontiers in Cellular Neuroscience·Ling XuFangxia Guan
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·YaDong LiuLiuCheng Ding
Jun 13, 2019·Cell Communication and Signaling : CCS·Huahong YangLiping Peng
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Yi-Ting ZhouJin-Wen Xu
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Peifang CongMingxiao Hou
Jan 5, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Yamin WangPeng Liu
Mar 11, 2021·Toxicology and Applied Pharmacology·Konghuai WangShufan Zhao
Dec 17, 2020·Aging·Xiaolong ChenGenshu Wang
Apr 17, 2021·PeerJ·Haoxian WangXianyun Fu
Apr 27, 2021·Frontiers in Pharmacology·Wenjie LiuGuanfeng Yao
May 19, 2021·Journal of Cardiovascular Pharmacology·Feng JiaoFan Fan
Jun 7, 2021·Journal of Ethnopharmacology·Xiaoli ZhaoTian Xia
Jul 1, 2021·Journal of Cellular Physiology·Mehrdad Hajinejad, Sajad Sahab-Negah
Aug 3, 2021·Frontiers in Pharmacology·Ping WangHongjun Yang
Feb 13, 2019·ACS Chemical Neuroscience·Hui WangJianqiang Yu
Sep 3, 2021·Brain and Behavior·Cailian RuanHaixia Lv
Nov 11, 2021·ACS Chemical Neuroscience·Qinyuan ZhaoHaiyan Zhang