PMID: 6412249Jun 1, 1983Paper

6-OHDA induced effects upon the acquisition and performance of specific locomotor tasks in rats

Pharmacology, Biochemistry, and Behavior
M Watson, J G McElligott

Abstract

The effect of norepinephrine (NE) depletion on acquisition and performance of locomotor tasks requiring precise paw placement was tested. Running times (RT, 25 trials/day, 4 consecutive days) of water-deprived rats trained to transverse horizontal rods in an equally spaced regular rod arrangement (REG) were obtained before and after (REG/REG) intracisternal 6-hydroxydopamine (6-OHDA, 3 X 25 micrograms free base) infusion. No significant differences from ascorbate (0.1%) vehicle controls were seen. Additional rats were tested using the same protocol except a more difficult, irregularly spaced rod arrangement (IRR) was used. These IRR/IRR rats also revealed no significant differences. However, testing on the REG task before, and the new IRR task after infusion produced impaired performance on days 3 and 4 when 6-OHDA and vehicle treated rats were compared. These REG/IRR rats also showed a significant difference in the slope of the line reflecting the decrease in RT over the 4 day post-infusion period. Since no differences in intertrial intervals or extinction behavior were seen, the effect was not attributed to differences in arousal or motivational state. This effect could not be attributed to a simple reduction in non-specific ...Continue Reading

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Citations

Aug 22, 2001·Microscopy Research and Technique·P C BickfordA C Granholm
Jan 1, 1990·Experimental Brain Research·J van NeervenJ van der Steen
Jan 1, 1987·Physiology & Behavior·E BrennerJ Van der Gugten
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Mar 10, 2015·Journal of Integrative Neuroscience·Daniel LopatinJerome Cohen
Nov 13, 2004·Behavioral and Cognitive Neuroscience Reviews·M Claire CartfordPaula C Bickford
Jun 12, 2003·Cell Transplantation·V ZamanA Ch Granholm
Aug 28, 2020·Frontiers in Cellular Neuroscience·Timothy M LockeErik S Carlson
Apr 1, 2003·Cell Transplantation·V ZamanA Ch Granholm

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