6-oxo-PGF(1 alpha)and 8-epi-PGF(2 alpha)in the arterial wall layers of various species: a comparison between intact and atherosclerotic areas

Prostaglandins, Leukotrienes, and Essential Fatty Acids
A OguoghoH Sinzinger

Abstract

PGI(2)and 8-epi-prostaglandin(PG)F(2 alpha)are antagonizing compounds. For both a key role in vascular pathology has been hypothesized. The isoprostane 8-epi-PGF(2 alpha)and the stable derivative of PGI(2), 6-oxo-PGF(1 alpha)were determined immunologically in the arterial wall of various species including humans. Human arterial tissue contained the highest amounts of 8-epi-PGF(2 alpha)and synthesized the lowest PGI(2). A significant negative correlation between 8-epi-PGF(2 alpha)and 6-oxo-PGF(1 alpha)was observed. Atherosclerotic segments showed significantly higher 8-epi-PGF(2 alpha)and lower 6-oxo-PGF(1 alpha). 8-epi-PGF(2 alpha)in the intima was higher than in the media, the highest amounts being found in foam-cell rich areas. Synthetic (activated) smooth muscle cells were associated with an enhanced 8-epi-PGF(2 alpha)as well as 6-oxo-PGF(1 alpha). Tissue samples derived from smokers contained more 8-epi-PGF(2 alpha)and produced less PGI(2). The by far highest 8-epi-PGF(2 alpha)/6-oxo-PGF(1 alpha)ratio was found in foam cell rich areas. Similar findings were obtained in rabbit and in minipig arteries. The total 8-epi-PGF(2 alpha)/6-oxo-PGF(1 alpha)ratio is low in normal tissue, increases significantly in an active atheroscle...Continue Reading

References

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Citations

Jan 8, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Edzard Schwedhelm, Rainer H Böger
Nov 6, 2007·Clinical Endocrinology·MaryFran SowersBill Lasley
Mar 15, 2008·Menopause : the Journal of the North American Menopause Society·Carlos HermenegildoAntonio Cano
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Carlos HermenegildoAntonio Cano
Apr 15, 2004·Free Radical Biology & Medicine·Sean S DaviesL Jackson Roberts

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