PMID: 1200981Dec 1, 1975Paper

6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci

Biochemical Genetics
V M Chapman

Abstract

An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m. musculus is interfertile with inbred strains of mice, and F1 hybrids with C57BL/6J show a three-banded phenotype. This pattern is consistent with a dimeric enzyme structure with codominant expression of alleles. In backcrosses and the F2 generation, PGD segregated as a singly autosomal gene, designated Pgd, closely linked to Gpd-1 on chromosome 4(1.7 +/- 1.1%). Both gene products are dimers, both require NADP, and these enzymes catalyze sequential steps in metabolism.

References

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Citations

Jan 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J P StoyeS Best
Apr 1, 1978·Biochemical Genetics·R S Holmes, C J Masters
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C M AbbottR Wiseman
Jan 11, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R BlankB Mock
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H Nadeau, M Kosowsky
Nov 1, 1976·In Vitro·J D MinnaU Francke
Aug 1, 1991·Mutation Research·J Peters, S E Lewis
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P A LalleyJ D Minna
Oct 1, 1977·Journal of Immunogenetics·R P Erickson
Jan 15, 1979·International Journal of Cancer. Journal International Du Cancer·S S ParkU Francke
Jan 1, 1981·Animal Blood Groups and Biochemical Genetics·R S Holmes, G P Timms

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