6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yun XuQinggui Zhang

Abstract

The prevalence of type 2 diabetes mellitus has been increasing worldwide and more than two thirds of the patients may develop diabetic nephropathy (DN). However, the efficiency of existing approaches on DN progression is limited. 6-Shogaol (6-SG), a major dehydrated derivative of gingerols, possesses various biological properties. The present study was designed to evaluate the possible effects of 6-SG on DN in db/db mice and to investigate the mechanisms. We revealed that 6-SG reduced the levels of fasting blood glucose, serum insulin, C-peptide, glycosylated hemoglobin A1c, and systolic blood pressure. 6-SG decreased the levels of blood urea nitrogen (BUN), serum creatinine, urinary albumin content and albumin/creatinine ratio (ACR), ameliorated the pathological injuries of kidneys, reduced the surface area of Bowman's capsule, Bowman's space, glomerular tuft, and decreased the expression of collagen IV and fibronectin in kidneys of db/db mice. The high levels of systemic and renal triglyceride and cholesterol were decreased by 6-SG. Moreover, 6-SG exhibited anti-inflammatory effects, as reflected by reduction of tumor necrosis factor ɑ (TNFɑ), monocyte chemotactic protein-1 (MCP-1), and IL-6 levels in circulation and kidneys,...Continue Reading

Citations

Apr 3, 2018·Toxicology Mechanisms and Methods·Nehal M ElsherbinyMohamed El-Sherbiny
Oct 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kohei NonakaJun-Ichi Kido
Jul 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nada H EisaEman Said
Oct 2, 2021·Journal of Animal Physiology and Animal Nutrition·Akhand ManiJeena Gupta
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fang ChenXiaoguang Zhu

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