60-minute application of S-Caine Peel prior to 1,064 nm long-pulsed Nd:YAG laser treatment of leg veins

Lasers in Surgery and Medicine
Ming H JihLeonard H Goldberg

Abstract

Advancements in laser treatment of leg veins necessitate concurrent investigations in topical anesthesia to minimize treatment-related pain. To evaluate the efficacy of the S-Caine Peel for providing topical anesthesia after a 60-minute application. A randomized, double-blinded, placebo-controlled trial was performed in two centers. Sixty patients received S-Caine Peel and placebo vehicle on different treatment sites for 60 minutes prior to laser treatment of leg veins using a 1,064 nm long-pulsed Nd:YAG laser. Patients rated their level of pain using a visual analog scale. Adequacy of anesthesia and expressed pain at each site were rated by the investigator. The mean visual analog scale (VAS) was 27 mm for active sites compared to 43 mm for placebo (P < 0.001). Improved pain relief was noted for 67% of active versus 30% of placebo sites (P < 0.001). Anesthesia was judged adequate by the investigator for 55% of active compared with 12% of placebo sites (P < 0.001). The S-Caine Peel is safe and effective when applied for 60 minutes prior to laser therapy of leg veins.

References

Nov 1, 1990·The Journal of Dermatologic Surgery and Oncology·R Ashinoff, R G Geronemus
Sep 22, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J S Dover
Jul 25, 2000·Journal of the American Academy of Dermatology·W Huang, A Vidimos
Sep 5, 2002·Lasers in Surgery and Medicine·Dilip Y PaithankarBradley S Graham

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Citations

Jun 4, 2008·Plastic and Reconstructive Surgery·Susan Kaweski, UNKNOWN Plastic Surgery Educational Foundation Technology Assessment Committee
Sep 1, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Tina S Alster
Aug 25, 2007·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Saundra E Curry, Julia C Finkel
Jan 21, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·K GrevelingM B A van Doorn
Jan 27, 2019·Experimental and Therapeutic Medicine·Gabriel IanosiDaniela Neagoe
Nov 13, 2021·Journal of Cosmetic Dermatology·Juan Jimenez-CauheCarlos Serra

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