60 YEARS OF POMC: Lipotropin and beta-endorphin: a perspective

Journal of Molecular Endocrinology
D G Smyth

Abstract

Many important fields of research had a humble origin. In the distant past, A J P Martin's discovery that amino acids could be separated by paper chromatography and Moore and Stein's use of columns for quantitative amino acid analysis provided the first steps towards the determination of structure in complex biologically active molecules. They opened the door to reveal the essential relationship that exists between structure and function. In molecular endocrinology, for example, striking advances have been made by chemists with their expertise in the identification of structure working with biologists who contributed valuable knowledge and experience. Advantage was gained from the convergence of different background, and it is notable that the whole is greater than the sum. In the determination of structure, it may be recalled that four of the world's great pioneers (Archibald Martin, Rodney Porter, Fred Sanger and Vincent du Vigneaud) were acknowledged for their fundamental contributions when individually they were awarded the Nobel Prize. They foresaw that the identification of structure would prove of outstanding importance in the future. Indeed, study of the structures of β-endorphin and enkephalin and the different forms o...Continue Reading

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Citations

Jun 9, 2016·Journal of Molecular Endocrinology·Adrian J L Clark, Philip Lowry
Aug 30, 2018·Physiological Reviews·Erika HarnoAnne White
Sep 17, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrew R RauShane T Hentges
Aug 18, 2020·Neuroscience Letters·Jun-Ichi ShiraishiTakashi Bungo
Jan 7, 2021·Biology of Reproduction·Kenneth L CampbellUma Vadher
Jan 6, 2021·International Journal of Molecular Sciences·Alexander PilozziXudong Huang
Sep 3, 2021·Neural Regeneration Research·Shu-Ju WangKeith A Candiotti

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