60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression

Journal of Molecular Endocrinology
J Drouin

Abstract

Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that reflect the developmental history of POMC-expressing cells of the pituitary and hypothalamus, as well as their critical role in the endocrine system. These inputs are integrated at specific regulatory sequences within the promoter and pituitary or hypothalamic enhancers of the POMC locus. Investigations of developmental mechanisms and transcription factors (TFs) responsible for pituitary activation of POMC transcription led to the discovery of the Pitx factors that have critical roles in pituitary development and striking patterning functions in embryonic development. Terminal differentiation of the two pituitary POMC lineages, the corticotrophs and melanotrophs, is controlled by Tpit; mutations of the human TPIT gene cause isolated adrenocorticotrophic hormone deficiency. Intermediate lobe and melanotroph identity is provided by the pioneer TF Pax7 that remodels chromatin to reveal a new repertoire of enhancers for Tpit action. Many signaling pathways regulate POMC transcription including activation by hypothalamic corticotrophin-releasing hormone acting through the orphan nuclear receptors of the Nur family and feedback repression by glucocorti...Continue Reading

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Citations

Oct 22, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Sundhar RamalingamMichael R Harrison
Aug 30, 2018·Physiological Reviews·Erika HarnoAnne White
Jul 16, 2017·Endocrine-related Cancer·Luis G Perez-RivasMarily Theodoropoulou
Jan 31, 2018·G3 : Genes - Genomes - Genetics·Jessica P HekmanAnna V Kukekova
Sep 22, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Bonnie C CarneyDean S Rosenthal
Jun 18, 2020·Journal of Clinical Medicine·Araceli García-MartínezAntonio Picó
Aug 19, 2018·Clinical Chemistry and Laboratory Medicine : CCLM·Verena GoundenIshwarlal Jialal
Jun 6, 2019·Frontiers in Nutrition·Martha A Schalla, Andreas Stengel
Feb 13, 2020·Nature Communications·Beate LeppertTobias Polte
Oct 3, 2020·Nutrients·Lionel Carneiro, Corinne Leloup
Nov 17, 2020·Thyroid : Official Journal of the American Thyroid Association·Rafael Maso PrévideStanko S Stojilkovic
Dec 31, 2019·Cancer Cell·Mario NeouGuillaume Assié
Dec 4, 2020·International Journal of Molecular Sciences·Hidenori FukuokaYutaka Takahashi
Apr 4, 2021·International Journal of Molecular Sciences·Marie-Pierre Moisan
Aug 22, 2021·Endocrinology·Logan J MassmanStephanie Olivier-Van Stichelen
Apr 18, 2019·Neuroendocrinology·Denis CiatoGünter Karl Stalla

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