68 Ga-BBN-RGD PET/CT for GRPR and Integrin αv β3 Imaging in Patients with Breast Cancer

Theranostics
Jingjing ZhangXiaoyuan Chen

Abstract

Purpose: This study was to assess a gastrin-releasing peptide receptor (GRPR) and integrin αvβ3 dual targeting tracer 68Ga-BBN-RGD for positron emission tomography (PET)/computed tomography (CT) imaging of breast cancer and metastasis. Materials and Methods: Twenty-two female patients were recruited either with suspected breast cancer on screening mammography (n = 16) or underwent breast cancer radical mastectomy (n = 6). All the 22 patients underwent PET/CT at 30-45 min after intravenous injection of 68Ga-BBN-RGD. Eleven out of 22 patients also accepted 68Ga-BBN PET/CT within 2 weeks for comparison. A final diagnosis was made based on the histopathologic examination of surgical excision or biopsy. Results: Both the primary cancer and metastases showed positive 68Ga-BBN-RGD accumulation. The T/B ratios of 68Ga-BBN-RGD accumulation were 2.10 to 9.44 in primary cancer and 1.10 to 3.71 in axillary lymph node metastasis, 3.80 to 10.7 in distant lymph nodes, 2.70 to 5.35 in lung metastasis and 3.17 to 22.8 in bone metastasis, respectively. For primary lesions, the SUVmax from 68Ga-BBN-RGD PET in ER positive group was higher than that in ER negative group (P < 0.01). For both primary and metastatic lesions, SUVmean quantified from 68...Continue Reading

Citations

Mar 4, 2020·Thyroid : Official Journal of the American Thyroid Association·Joanna Klubo-Gwiezdzinska, Xiaoyuan Chen
May 28, 2020·Cancers·Joseph LauXiaoyuan Chen
Aug 6, 2020·Pharmaceuticals·Benedikt JudmannCarmen Wängler
Sep 29, 2020·OncoTargets and Therapy·Zhenhui NieDanke Su
Sep 13, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Thomas EbenhanMike Sathekge
Jul 15, 2020·Nuclear Medicine and Biology·Hidefumi Mukai, Yasuyoshi Watanabe
Dec 29, 2020·Physiological Reviews·Philippe ClézardinIngunn Holen
Jul 17, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Zhaoguo HanXilin Sun
Jan 5, 2019·Bioconjugate Chemistry·Sebastien BenizriPhilippe Barthélémy
Dec 17, 2020·Bioconjugate Chemistry·Paweł KręciszPaweł Szymański
Sep 11, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Jing-Jing LiuGuo-Jun Zhang

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT02749019

Software Mentioned

Prism
GraphPad

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