68 Ga-PSMA and 11 C-Choline comparison using a tri-modality PET/CT-MRI (3.0 T) system with a dedicated shuttle

European Journal of Hybrid Imaging
Omar AlonsoHenry Engler

Abstract

The aim of this study was to prospectively compare the detection rate of 68Ga-PSMA versus 11C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality PET/CT-MRI system. We analysed 36 patients who underwent both 11C-Choline PET/CT and 68Ga-PSMA PET/CT scanning within a time window of 1-2 weeks. Additionally, for the 68Ga-PSMA scan, we used a PET/CT-MRI (3.0 T) system with a dedicated shuttle, acquiring MRI images of the pelvis. Both scans were positive in 18 patients (50%) and negative in 8 patients (22%). Nine patients were positive with 68Ga-PSMA alone (25%) and one with 11C-Choline only (3%). The median detected lesion per patient was 2 for 68Ga-PSMA (range 0-93) and 1 for 11C-Choline (range 0-57). Tumour to background ratios in all concordant lesions (n = 96) were higher for 68Ga-PSMA than for 11C-Choline (110.3 ± 107.8 and 27.5 ± 17.1, mean ± S.D., for each tracer, respectively P = 0.0001). The number of detected lesions per patient was higher for 11C-Choline in those with PSA ≥ 3.3 ng/mL, while the number of detected lesions was independent of PSA levels for 68Ga-PSMA using the same PSA cut-off value. Metastatic pelvic lesions were found in 25 patients (69%) wit...Continue Reading

References

May 8, 2000·The Journal of Urology·J W Moul
Dec 14, 2004·The Journal of Urology·Sandi A KweeJehoon P Ko
Apr 29, 2005·Radiology·Daniel T SchmidThomas F Hany
Jul 30, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Takako YamaguchiTomio Inoue
Nov 30, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martin HeinischWerner Langsteger
Apr 12, 2006·Nature Clinical Practice. Urology·Neil H Bander
Jul 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marino CimitanMauro G Trovò
Sep 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·B J KrauseM Schwaiger
Oct 11, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Daniela B HusarikThomas F Hany
Jun 4, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Sandi A Kwee, Tim DeGrado
Sep 20, 2008·Pathology Oncology Research : POR·Sebastian MannweilerGabor Mehes
Feb 13, 2009·Nuklearmedizin. Nuclear Medicine·Ch SteinerF Buchegger
Aug 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Paolo CastellucciStefano Fanti
Aug 20, 2010·Journal of Medical Imaging and Radiation Oncology·J-M BeauregardR J Hicks
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 16, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael SouvatzoglouBernd Joachim Krause
Feb 9, 2012·European Journal of Nuclear Medicine and Molecular Imaging·A Afshar-OromiehC M Zechmann
Mar 7, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Matthias EderUwe Haberkorn
Apr 18, 2013·Current Topics in Medicinal Chemistry·Ronnie C MeaseMartin G Pomper
Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Jan 24, 2014·AJR. American Journal of Roentgenology·Maarten de RooijMaroeska M Rovers
Mar 21, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Matthias EiberMarkus Schwaiger
Aug 26, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Johannes SchwenckChristian la Fougère
Jun 29, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn

❮ Previous
Next ❯

Citations

Jan 16, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edouard J TrabulsiH Alberto Vargas
Nov 11, 2019·Der Urologe. Ausg. A·A Afshar-OromiehA Rominger
Feb 14, 2021·Revista española de medicina nuclear e imagen molecular·J R GarciaJ M Santabarbara
Jul 6, 2020·Seminars in Ultrasound, CT, and MR·Manil SubesingheGary J Cook

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique

Software Mentioned

GraphPad Prism
OsiriX

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.