68 Ga-PSMA-PET/CT for the evaluation of pulmonary metastases and opacities in patients with prostate cancer.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society
Jonathan DamjanovicMarcus R Makowski

Abstract

The purpose of this study was to investigate the imaging properties of pulmonary metastases and benign opacities in 68Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC). 68Ga-PSMA-PET/CT scans of 739 PC patients available in our database were evaluated retrospectively for lung metastases and non-solid focal pulmonary opacities. Maximum standardized uptake values (SUVmax) were assessed by two- and three-dimensional regions of interest (2D/3D ROI). Additionally CT features of the lesions, such as location, morphology and size were identified. Ninety-one pulmonary metastases and fourteen opacities were identified in 34 PC patients. In total, 66 PSMA-positive (72.5%) and 25 PSMA-negative (27.5%) metastases were identified. The mean SUVmax of pulmonary opacities was 2.2±0.7 in 2D ROI and 2.4±0.8 in 3D ROI. The mean SUVmax of PSMA-positive pulmonary metastases was 4.5±2.7 in 2D ROI and in 4.7±2.9 in 3D ROI; this was significantly higher than the SUVmax of pulmonary opacities in both 2D and 3D ROI (p<0.001). The mean SUVmax of PSMA-negative metastases was 1.0±0.5 in 2D ROI and 1.0±0.4 in 3D ROI, and significantly lower than that of the pulmonary opacities (p<0.001). A significant (p<0.05) weak linear corr...Continue Reading

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Citations

Oct 26, 2018·Clinical Nuclear Medicine·Kai HuangChristian Furth
Jul 31, 2019·Clinical Nuclear Medicine·Nikhil SeniarayHarsh Mahajan
Dec 11, 2020·Nuklearmedizin. Nuclear Medicine·Huijuan LiuHuipan Liu
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Sep 29, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Akira ToriiharaAndrei Iagaru
Sep 3, 2021·Chemical Biology & Drug Design·Pejman ShahrokhiFarzaneh Rezazadeh
Nov 13, 2021·The British Journal of Radiology·Feng-Yuan LiuGigin Lin

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