68 Ga]PSMA PET/CT Improves Initial Staging and Management Plan of Patients with High-Risk Prostate Cancer

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Nader HirmasSamer Salah

Abstract

In this retrospective study, we compared the diagnostic value of 68Gallium prostate-specific membrane antigen positron emission tomography computed tomography ([68Ga]PSMA PET/CT) in primary staging of patients with high-risk prostate cancer (PCa), in comparison to CT, magnetic resonance imaging (MRI), and bone scans, and we explored its overall impact on patients' management plan. Patients with pathological confirmation of PCa with high-risk disease were included in this study. Information on patient demographics, clinical and histopathological findings with Gleason score and initial prostate specific antigen PSA levels, and radiological findings for CT, MRI, bone scan, and [68Ga]PSMA PET/CT were retrieved. We stratified the concordance and discordance of each imaging modality on per-patient and per-lesion-site bases. Twenty-one patients with high-risk disease were included in this study. [68Ga]PSMA PET/CT revealed a significantly higher concordance rate (90 %) compared to the concordance rates of bone scan (75 %), MRI (73 %), and CT (60 %). [68Ga]PSMA PET/CT had a similar accuracy to MRI in detecting prostate lesions but a higher accuracy for suspicious pelvic lymph nodes (95.2 % vs. 80 %). It also superseded CT scan in detect...Continue Reading

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Citations

May 25, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E LopciM Lazzeri
Mar 5, 2019·Nuclear Medicine and Molecular Imaging·Akram Al-Ibraheem, Ali Mohamedkhair
Sep 4, 2020·Computational and Mathematical Methods in Medicine·Jun ZhangKanghuai Liu
Oct 20, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Daniela A FerraroIrene A Burger
Feb 6, 2021·European Urology Focus·Vishnu MurthyThomas A Hope
Jan 12, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ida SonniJeremie Calais
Apr 19, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Le Wen ChiuRobert R Flavell

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