(68)Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Glioblastoma

Theranostics
Constantin LapaKen Herrmann

Abstract

Chemokine receptor-4 (CXCR4) has been reported to be overexpressed in glioblastoma (GBM) and to be associated with poor survival. This study investigated the feasibility of non-invasive CXCR4-directed imaging with positron emission tomography/computed tomography (PET/CT) using the radiolabelled chemokine receptor ligand (68)Ga-Pentixafor. 15 patients with clinical suspicion on primary or recurrent glioblastoma (13 primary, 2 recurrent tumors) underwent (68)Ga-Pentixafor-PET/CT for assessment of CXCR4 expression prior to surgery. O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET/CT images were available in 11/15 cases and were compared visually and semi-quantitatively (SUVmax, SUVmean). Tumor-to-background ratios (TBR) were calculated for both PET probes. (68)Ga-Pentixafor-PET/CT results were also compared to histological CXCR4 expression on neuronavigated surgical samples. (68)Ga-Pentixafor-PET/CT was visually positive in 13/15 cases with SUVmean and SUVmax of 3.0±1.5 and 3.9±2.0 respectively. Respective values for (18)F-FET were 4.4±2.0 (SUVmean) and 5.3±2.3 (SUVmax). TBR for SUVmean and SUVmax were higher for (68)Ga-Pentixafor than for (18)F-FET (SUVmean 154.0±90.7 vs. 4.1±1.3; SUVmax 70.3±44.0 and 3.8±1.2, p<0.01), respecti...Continue Reading

Associated Clinical Trials

Citations

Feb 6, 2017·International Journal of Molecular Sciences·Sriram SridharBalázs Gulyás
Nov 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Weijun WeiWeibo Cai
Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Gagandeep ChoudharyJonathan McConathy
Sep 25, 2019·Molecular Pharmacology·Ilze AdlereRob Leurs
Mar 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan-Michael WernerNorbert Galldiks
Mar 12, 2018·Journal of Neuro-oncology·Vladimir KepeErnest M Wright
Apr 3, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Hanwen ZhangRonald Blasberg
Mar 31, 2017·Current Cardiovascular Imaging Reports·Malte Kircher, Constantin Lapa
Mar 9, 2018·Oncotarget·Maria BreunCarsten Hagemann
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·Andreas PoschenriederHans-Jürgen Wester
Jun 28, 2019·Frontiers in Oncology·Maria BreunConstantin Lapa
Jul 30, 2019·Frontiers in Pharmacology·Clément BaillyMickaël Bourgeois
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Apr 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alejandro Amor-CoarasaJohn W Babich
Oct 23, 2020·Journal of Leukocyte Biology·Miguel MartinAlexandra Bobirca
Nov 20, 2020·Clinical Nuclear Medicine·Angelika M StarzerMarius E Mayerhoefer
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xenograft
surgical
biopsy
surgical resection

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SPSS
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